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Postion:Product Catalog >BIO-1211
BIO-1211
  • BIO-1211

BIO-1211 NEW

Price $113 $168 $289
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-11

Product Details

Product Name: BIO-1211 CAS No.: 187735-94-0
Purity: 99.33% Supply Ability: 10g
Release date: 2024/11/11

Product Introduction

Bioactivity

名稱BIO-1211
描述BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
體外活性BIO-1211 does not show activity against α1β1, α5β1, α6β1, αLβ2 and αIIbβ3[2].
體內(nèi)活性In naive, C57BL/6 mice, BIO-1211 exhibited a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex. BIO-1211 resulted in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in a dose-independent manner[1].
存儲條件keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 250 mg/mL (352.71 mM)
關鍵字inhibit | Integrin | BIO1211 | BIO-1211 | BIO 1211 | Inhibitor
相關產(chǎn)品K34c hydrochloride | E7820 | Tirofiban hydrochloride monohydrate | Lifitegrast | Elarofiban TFA | Cyclo(-RGDfK) | Bestatin hydrochloride | RO0270608 | ICAM-1-IN-1 | Gantofiban
相關庫經(jīng)典已知活性庫 | ReFRAME 相關化合物庫 | 多肽分子庫 | 抑制劑庫 | 口服活性化合物庫 | 已知活性化合物庫 | 共價抑制劑庫 | 細胞骨架化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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