BIO-1211 NEW
Price | $113 | $168 | $289 |
Package | 1mg | 2mg | 5mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-11 |
Product Details
Product Name: BIO-1211 | CAS No.: 187735-94-0 |
Purity: 99.33% | Supply Ability: 10g |
Release date: 2024/11/11 |
Product Introduction
Bioactivity
名稱 | BIO-1211 |
描述 | BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM). |
體外活性 | BIO-1211 does not show activity against α1β1, α5β1, α6β1, αLβ2 and αIIbβ3[2]. |
體內(nèi)活性 | In naive, C57BL/6 mice, BIO-1211 exhibited a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex. BIO-1211 resulted in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in a dose-independent manner[1]. |
存儲條件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 250 mg/mL (352.71 mM) |
關鍵字 | inhibit | Integrin | BIO1211 | BIO-1211 | BIO 1211 | Inhibitor |
相關產(chǎn)品 | K34c hydrochloride | E7820 | Tirofiban hydrochloride monohydrate | Lifitegrast | Elarofiban TFA | Cyclo(-RGDfK) | Bestatin hydrochloride | RO0270608 | ICAM-1-IN-1 | Gantofiban |
相關庫 | 經(jīng)典已知活性庫 | ReFRAME 相關化合物庫 | 多肽分子庫 | 抑制劑庫 | 口服活性化合物庫 | 已知活性化合物庫 | 共價抑制劑庫 | 細胞骨架化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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