Befiradol hydrochloride NEW
| Price | $152 | $378 | $553 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Befiradol hydrochloride | CAS No.: 2436760-81-3 |
| Purity: 99.1% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Befiradol hydrochloride |
| Description | Befiradol hydrochloride (NLX-112 hydrochloride) is a selective 5-hydroxytryptamine 1A (5-HT1A) receptor agonist with anxiolytic properties and inhibits mutant ATXN3 aggregation. |
| In vivo | Befiradol hydrochloride (F13640 hydrochloride; NLX-112 hydrochloride) decreases the activity of dorsal raphe serotonergic neurons when administered intravenously at doses ranging from 0.2 to 18.2 μg/kg, with an effective dose (ED50) of 0.69 μg/kg, i.v. At the same dosage range, it enhances the firing rate of 80% of the medial prefrontal cortex (mPFC) pyramidal neurons, with an ED50 of 0.62 μg/kg, i.v.[1] Befiradol hydrochloride (0.04-0.63 mg/kg; i.p.) dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC.[1] Befiradol hydrochloride (0.01-2.5 mg/kg; i.p.) dose-dependently increases extracellular DA in mPFC, an effect dependent on the activation of postsynaptic 5-HT1A receptors in mPFC. Local perfusion of Befiradol hydrochloride in mPFC (1-1000 μM) also increases extracellular DA in a concentration-dependent manner.[1] |
| Storage | Shipping with blue ice. |
| Solubility Information | DMSO : 43.03 mg/mL (100 mM), Sonication is recommended. |
| Keywords | Befiradol Hydrochloride | F-13640 Hydrochloride | NLX112 Hydrochloride | F 13640 Hydrochloride | F13640 Hydrochloride | NLX 112 Hydrochloride | NLX-112 Hydrochloride |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | Trazodone hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| $75.00/2mg |
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TargetMol Chemicals Inc.
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2024-10-28 | |
| $0.00/1kg |
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Wuhan Senwayer Century Chemical Co.,Ltd
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2022-10-28 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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