Bay 11-7085 NEW
| Price | $30 | $43 | $61 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Bay 11-7085 | CAS No.: 196309-76-9 |
| Purity: 99.83% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱(chēng) | Bay 11-7085 |
| 描述 | Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM). |
| 細(xì)胞實(shí)驗(yàn) | Human umbilical vein endothelial cells (HUVEC) are isolated and maintained in culture. Cell toxicity is assessed by morphology and by MTT assay.(Only for Reference) |
| 激酶實(shí)驗(yàn) | In Gel Kinase Assay: In gel kinase assay for the proteins that phosphorylate IκB-α is carried out as detailed below. Whole cell extracts are prepared from HUVEC treated with TNFα (100 units/ml) for 15 min in the presence or absence of inhibitor (20 μM, pretreatment for 1 h) as indicated. Proteins are separated on a 10% SDS gel containing 0.5 mg/ml HIS-IκB-α. Gels are washed two times in 20% propanol, 50 mM Hepes, pH 7.6, for 30 min and two times in buffer A (50 mM Hepes, pH 7.6, 5 mM 2-mercaptoethanol) for 30 min, followed by a 1-h incubation with buffer A containing 6 M urea, 1 h each in 3, 1.5, and 0.75 M urea in buffer A and 0.05% Tween 20 and 1 h in buffer A with 0.05% Tween 20. The kinase assay is carried out for 1 h at 30?°C in the presence of 50 μM ATP, 5 μCi/ml [32P]ATP, 20 mM Hepes, pH 7.6, 20 mM MgCl2, 20 mM β-glycerophosphate, 20 mM p-nitrophenyl phosphate, 1 mM sodium vanadate, 2 mM dithiothreitol. The gel is washed with 5% trichloroacetic acid and 1% sodium pyrophosphate, dried, and exposed to film. A separate gel with no HIS-IκB-α is assayed as a control. |
| 體外活性 | In athymic nude mice harboring Caov-3 cells, BAY 11-7085 enhances the inhibitory effect of paclitaxel on intraperitoneal spread and ascites formation. Additionally, BAY 11-7085 suppresses the increase in NF-κB activity associated with meningitis, improves the clinical condition of infected rats, and significantly reduces CNS complications and inflammation related to meningitis. |
| 體內(nèi)活性 | When used in conjunction with paclitaxel, BAY 11-7085 enhances the inhibition of NF-κB activity and reduces the survival rate of paclitaxel-treated cells. By inhibiting NF-κB, BAY 11-7085 suppresses the expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 induced by TNFα. BAY 11-7085 (10 μM) exhibits no cytotoxicity towards HUVEC cells. Moreover, the combined use of BAY 11-7085 and LY294002 synergistically influences apoptosis in PEL cells. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 24.9 mg/mL (100 mM) Ethanol : 24.9 mg/mL (100 mM) |
| 關(guān)鍵字 | BAY 11-7085 | Apoptosis | NF-κB | inhibit | Nuclear factor-κB | Ferroptosis | Inhibitor | Bay 11 7085 | Bay 117085 | Nuclear factor-kappaB | Bay 11-7085 |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Curcumin | L-Cystine | Diallyl disulfide |
| 相關(guān)庫(kù) | 高選擇性抑制劑庫(kù) | 經(jīng)典已知活性庫(kù) | 抗抑郁癥化合物庫(kù) | 抗乳腺癌化合物庫(kù) | 抗氧化化合物庫(kù) | 抑制劑庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) | 抗肝癌化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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