AZD3839 free base NEW
| Price | $48 | $116 | $178 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: AZD3839 free base | CAS No.: 1227163-84-9 |
| Purity: 99.96% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | AZD3839 free base |
| 描述 | AZD3839 free base is a potent and selective BACE1 inhibitor with a Ki of 26.1 nM, demonstrating approximately 14-fold selectivity over BACE2. [Phase 1] |
| 體外活性 | In SH-SY5Y cells, AZD3839 efficiently decreases the Aβ40 levels with IC50 of 4.8 nM, and decreases the formation of sAPPβ with IC50 of 16.7 nM. AZD3839 also decreases the Aβ40 levels secreted from C57BL/6 mouse primary cortical neurons, N2A cells, and Dunkin-Hartley guinea pig primary cortical neurons with IC50 values of 50.9, 32.2, and 24.8 nM, respectively. [1] AZD3839 causes in vitro BACE1 inhibition in the cell assay with IC50 value of 16.7 nM. [2] |
| 體內(nèi)活性 | In C57BL/6 mice, AZD3839 (69 mg/kg, p.o.) causes a dose- and time-dependent reduction of plasma and brain Aβ. In guinea pig and non-human primates, AZD3839 also inhibits Aβ generation. [1] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 80 mg/mL (185.4 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 80 mg/mL (185.4 mM) |
| 關(guān)鍵字 | AZD-3839 | AZD3839 free base | AZD 3839 | β-Secretase | BACE | AZD-3839 free base | inhibit | Beta-secretase | Inhibitor |
| 相關(guān)產(chǎn)品 | Eslicarbazepine Acetate | Auraptene | Verubecestat | DSS30 | Loganin | Atabecestat | LY2886721 | Phytic acid potassium | NB-360 | Epiberberine | Tenuifolin | Aloeresin D |
| 相關(guān)庫 | 神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 抗阿爾茨海默癥化合物庫 | ReFRAME 相關(guān)化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 干細(xì)胞分化化合物庫 | 已知活性化合物庫 | 共價抑制劑庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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