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Postion:Product Catalog >AZD-0284
AZD-0284
  • AZD-0284

AZD-0284 NEW

Price $89 $228 $347
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-01

Product Details

Product Name: AZD-0284 CAS No.: 2101291-07-8
Purity: 99.75% Supply Ability: 10g
Release date: 2024/11/01

Product Introduction

Bioactivity

名稱AZD-0284
描述AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
體外活性AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cells[1], reduces polarization of TH17 into pathogenic TH17/1 cells, decreases the frequency of IL-17+ cells and double positive TH17/1 cells, and reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22, and IL-23R[1][2].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 99 mg/mL (188.77 mM), Sonication is recommended.
關(guān)鍵字tract | RAR-related orphan receptor | AZD0284 | IL-17F | L-23R | Inhibitor | AZD-0284 | plaque | respiratory | vulgaris | production | IL-17A | TH17 | psoriasis | IL-22 | AZD 0284 | inhibit | cells | ROR
相關(guān)產(chǎn)品S18-000003 | Cedirogant | T0901317 | GSK2981278 | Nobiletin | XY101 | Cholesterol | Melatonin | SR2211 | Cabozantinib hydrochloride | RORγt Inverse agonist 6 | ML 209
相關(guān)庫核受體化合物庫 | 經(jīng)典已知活性庫 | ReFRAME 相關(guān)化合物庫 | 激酶抑制劑庫 | 藥物功能重定位化合物庫 | 代謝化合物庫 | 臨床期小分子藥物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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