Atorvastatin hemicalcium salt NEW
| Price | $45 | $53 | $61 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-20 |
Product Details
| Product Name: Atorvastatin hemicalcium salt | CAS No.: 134523-03-8 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2024/11/20 |
Product Introduction
Bioactivity
| Name | Atorvastatin hemicalcium salt |
| Description | Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an HMG-CoA reductase inhibitor with oral activity. Atorvastatin hemicalcium salt is used to lower cholesterol. |
| Cell Research | Briefly, SV-SMC from 5 different patients are seeded into 24-well cell culture plates at a density of 1×104?cells per well in full growth medium. Cells are incubated overnight and then quiesced in serum free medium for 3 days before transfer to full growth medium (10% FCS) containing 5 different statins (simvastatin, atorvastatin, fluvastatin, lovastatin, and pravastatin)at a range of concentrations. All statins are tested on cells from each individual patient. Medium and drugs are replaced after 2 days, and viable cell numbers are determined in triplicate wells after 4 days using Trypan Blue and a hemocytometer. The increase in cell number is calculated by subtracting the starting cell number (day 0) from the final cell number (day 4). Data are then normalized to control values (no statin) to correct for differences in proliferation rates between cells from different patients. |
| In vitro | METHODS: HCT-116, A375, MIA PaCa-2 and BJ hTERT cells were treated with CX5461 (0-10 μM) for 96 h and cell viability was measured by CyQUANT assay. RESULTS: Antiproliferative dose-response assessment of HCT-116, A375, and MIA PaCa-2 cell lines yielded EC50s of 167, 58, and 74 nmol/L, respectively. the EC50 of the BJ-hERT normal cell line was approximately 5000 nmol/L. [1] METHODS: CaSki cells were treated with CX5461 (1-5 μM) for 24-72 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: After CX5461 treatment, LC3I was completely converted to LC3II, while p62 expression was reduced. densitometric analysis of LC3I and LC3II bands showed that the LC3II:LC3I ratio was significantly increased after 72 h of CX5461 treatment. [2] |
| In vivo | METHODS: To assay antitumor activity in vivo, CX5461 (50 mg/kg, 50 mmol/L NaH2PO4 pH 4.5) was administered orally to mice bearing MIA PaCa-2 or A375 xenografts once daily or every three days for 32 days. RESULTS: CX5461 showed a significant MIA PaCa-2 TGI equal to 69% on day 31. Similarly, CX5461 showed a significant A375 TGI with a TGI of 79% on day 32. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (43.28 mM) |
| Keywords | Autophagy | Ferroptosis | inhibit | Inhibitor | Atorvastatin hemicalcium salt | Atorvastatin | HMG-CoA Reductase (HMGCR) | CI 981 | CI981 |
| Inhibitors Related | Stavudine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Paeonol | L-Cystine | Naringin | Gefitinib |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1.00/25KG |
VIP6Y
|
Hebei Weibang Biotechnology Co., Ltd
|
2024-11-11 | |
| $0.00/1g |
VIP1Y
|
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
|
2024-09-05 | |
| $500.00/1kg |
VIP1Y
|
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
|
2024-08-23 | |
| $0.00/1kg |
VIP4Y
|
Sinoway Industrial co., ltd.
|
2024-08-22 | |
| $50.00/1KG |
VIP4Y
|
Hebei Chuanghai Biotechnology Co,.LTD
|
2024-08-21 | |
| $0.00/1kg |
VIP1Y
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
2024-05-10 | |
| $15.00/1kg |
Ouhuang Engineering Materials (Hubei) Co., Ltd
|
2024-04-25 | ||
| $0.00/1kg |
Nanjing Fred Technology Co., Ltd
|
2024-01-04 | ||
| $0.00/1KG |
VIP2Y
|
Hangzhou ICH Biofarm Co., Ltd
|
2023-07-06 | |
| $200.00/1kg |
Hebei Mingeng Biotechnology Co., Ltd
|
2022-11-28 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY