ATN-161 trifluoroacetate salt NEW
| Price | $38 | $54 | $89 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: ATN-161 trifluoroacetate salt | CAS No.: 904763-27-5 |
| Purity: 99.98% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | ATN-161 trifluoroacetate salt |
| 描述 | ATN-161 trifluoroacetate salt (ATN-161 TFA salt) is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases and improves survival in a murine model. |
| 體外活性 | The co-administration of ATN-161 and 5-FU markedly reduces tumor cell growth more effectively than either treatment alone or the control. Additionally, this combined approach markedly elevates the levels of apoptotic (TUNEL-positive) tumor cells, a result not observed with single-agent treatments. Furthermore, ATN-161 demonstrates a 21% reduction in endothelial cell (EC) numbers after 48 hours compared to controls, highlighting its effectiveness. Importantly, ATN-161 also impedes VEGF-induced endothelial cell migration and capillary formation, although it does not affect their proliferation. It significantly decreases endothelial cell migration towards VEGF in a dose-dependent manner, beginning at 100 nM (P<0.001 vs. VEGF group), showcasing its potential in inhibiting angiogenesis[1][2]. |
| 體內(nèi)活性 | Initial tests on α5β1-negative human colon cancer xenografts (HT29) show ATN-161 significantly decreases tumor weight and vessel density [1]. Administering ATN-161 post-laser photocoagulation effectively suppresses choroidal neovascularization (CNV) leakage and new blood vessel formation, achieving results comparable to those with AF564 [2]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : Slightly soluble |
| 關鍵字 | ATN 161 trifluoroacetate salt | ATN 161 Trifluoroacetate | ATN161 trifluoroacetate salt | ATN-161 TFA | ATN161 | inhibit | ATN-161 | ATN 161 | Integrin | Inhibitor | ATN-161 Trifluoroacetate | ATN161 Trifluoroacetate |
| 相關產(chǎn)品 | K34c hydrochloride | E7820 | Arg-Gly-Asp TFA (99896-85-2(free base)) | Tirofiban hydrochloride monohydrate | Lifitegrast | Elarofiban TFA | Cyclo(-RGDfK) | Tirofiban | Bestatin hydrochloride | RO0270608 | ICAM-1-IN-1 | Gantofiban |
| 相關庫 | 經(jīng)典已知活性庫 | ReFRAME 相關化合物庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 血管生成庫 | 抑制劑庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | 抗癌藥物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $3700.00/100mg |
VIP1Y
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TargetMol Chemicals Inc.
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2024-10-28 | |
| $30.00/1mg |
VIP5Y
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TargetMol Chemicals Inc.
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2024-11-07 | |
| $10.00/1kg |
Nantong Guangyuan Chemicl Co,Ltd
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2023-11-15 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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