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Postion:Product Catalog >Atg4B-IN-2
Atg4B-IN-2
  • Atg4B-IN-2

Atg4B-IN-2 NEW

Price $115 $228 $380
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-12

Product Details

Product Name: Atg4B-IN-2 CAS No.: 2765008-88-4
Purity: 98.86% Supply Ability: 10g
Release date: 2024/11/12

Product Introduction

Bioactivity

名稱Atg4B-IN-2
描述Atg4B-IN-2. A potent, selective Atg4B inhibitor with anticancer activity, inhibits both Atg4B and PLA2, enabling autophagy that counteracts the anticancer activity of anti-desiccation-resistant prostate cancer drugs.
體外活性In a dose-dependent manner, Atg4B-IN-2 (compound 21f) (1-10 μM; 2 hours) restores p62 expression in cells treated with amino acid-free (AF) conditions [1]. At concentrations of 1 and 5 μM (2 hours), Atg4B-IN-2 moderately decreases autophagic vesicles at 1 μM and almost completely inhibits autophagy at 5 μM [1]. At a concentration of 5 μM (2 hours), Atg4B-IN-2 inhibits Abi-induced autophagy, significantly enhances apoptotic cell death, and increases sensitivity to Abi [1].
存儲條件Shipping with blue ice.
溶解度DMSO : 80 mg/mL (242.09 mM), Sonication is recommended.
相關(guān)產(chǎn)品Neomycin sulfate | Hydroxychloroquine | Guanidine hydrochloride
相關(guān)庫經(jīng)典已知活性庫 | 抑制劑庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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