Ataluren NEW
Price | Get Latest Price |
Package | 25KG |
Min. Order: | 1KG |
Supply Ability: | 5000kgs |
Update Time: | 2024-11-19 |
Product Details
Product Name: Ataluren | CAS No.: 775304-57-9 |
Min. Order: 1KG | Purity: 98% HPLC |
Supply Ability: 5000kgs | Release date: 2024/11/19 |
Ataluren activity, optimized using a reporter gene containing a nonsense enzyme, promotes dystrophin production in primary myocytes of human and mdx mice expressing a nonsense allele of dystrophin, and following drug exposure 2 - Rescue of striated muscle function in mdx mice over 8 weeks. Ataluren (PTC124) was tolerated in animals in plasma exposures substantially in excess of those required for nonsense inhibition[2]. To induce nonsense inhibition and increase PPT1 enzyme activity, 2-week-old male Cln1R151X mice were given the read-through drug Ataluren (PTC124) by intraperitoneal (ip) injection. In the proof-of-principle study, these treatments were performed four times daily for 2 consecutive days. Ataluren (PTC124) increased PPT1 enzyme activity (P = 0.0001 by unpaired t-test) and protein levels (P = 0.0014 by unpaired t-test) in liver at 10 mg/kg, but did not increase PPT1 enzyme activity or Protein levels in cortex. This tissue-specific effect may be due to the inability of Ataluren (PTC124) to disrupt the blood-brain barrier (BBB), which reduces the bioavailability of Ataluren (PTC124) in the brain and prevents Ataluren (PTC124) from reaching effective concentrations within the therapeutic window
Company Profile Introduction
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$32.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
$100.00/1kg |
VIP1Y
|
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
|
2024-08-15 | |
$50.00/1kg |
Anhui Ruihan Technology Co., Ltd
|
2023-09-06 | ||
$30.00/1kg |
Henan Bao Enluo International TradeCo.,LTD
|
2023-07-27 | ||
$0.00/25kg |
VIP2Y
|
Hangzhou ICH Biofarm Co., Ltd
|
2023-07-05 | |
$100.00/100Grams |
VIP3Y
|
Hebei Dangtong Import and export Co LTD
|
2023-03-06 | |
$0.00/1kg |
Chengdu Hepu Pharmaceutical Technology Co. , Ltd
|
2022-05-06 | ||
$15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-11 | ||
$2.00/1kg |
VIP7Y
|
Career Henan Chemical Co
|
2018-12-23 | |
$30.00/1kg |
Henan Bao Enluo International TradeCo.,LTD
|
2023-07-10 |
- Since: 2014-09-09
- Address: No.28 Hua Long Road,Ji Nan City,China
+86-13153181156
sales@sdperfect.com