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Postion:Product Catalog >ARV-471
ARV-471
  • ARV-471

ARV-471 NEW

Price $265 $657 $935
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: ARV-471 CAS No.: 2229711-68-4
Purity: 99.85% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱ARV-471
描述Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
體外活性Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM.
體內(nèi)活性Vepdegestrant (ARV-471) (3, 10, and 30 mpk/day, orally) demonstrated significant antitumor activity in estradiol-dependent MCF7 xenografts, with a greater than 90% reduction in ER protein; even more significant tumor growth inhibition (131% TGI) was observed in the MCF7 xenograft model, with a significant reduction in ER protein levels when combined with the CDK4/6 inhibitor palbociclib.[1]
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 100 mg/mL (138.14 mM), Sonication is recommended.
關(guān)鍵字oral | Inhibitor | breast cancer | PROTAC | E3 ligase | inhibit | hetero-bifunctional | ARV 471 | ubiquitylation | PROTACs | Estrogen Receptor/ERR | ARV471 | estrogen receptor | proteasome | ARV-471
相關(guān)產(chǎn)品Kaempferol | Tamoxifen | Estradiol | Estradiol benzoate | Genistin | Cholesterol | Estriol | Chrysin | Ethisterone | Estrone
相關(guān)庫經(jīng)典已知活性庫 | 藥物功能重定位化合物庫 | 內(nèi)分泌激素分子庫 | 口服活性化合物庫 | 已知活性化合物庫 | 抗癌化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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