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Postion:Product Catalog >APX-115
APX-115
  • APX-115

APX-115 NEW

Price $30 $73 $118
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-11

Product Details

Product Name: APX-115 CAS No.: 1395946-75-4
Purity: 99.68% Supply Ability: 10g
Release date: 2024/11/11

Product Introduction

Bioactivity

名稱APX-115
描述APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
體外活性In the mouse podocyte cell line, APX-115 (5?μM; 60?min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression. In the kidney, APX-115 attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes [2].
體內(nèi)活性APX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels. APX-115 (oral gavage; 60?mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice[1].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 90 mg/mL (285 mM), Sonication is recommended.
關(guān)鍵字APX115 | APX-115 | APX 115
相關(guān)產(chǎn)品GLX351322 | APX-115 free base | NoxA1ds acetate(1435893-78-9 free base) | NecroX-7 | Ketoconazole | Aucuparin | Protosappanin A | Phox-I2 | ML-090 | GKT136901 | Setanaxib | VAS 3947
相關(guān)庫經(jīng)典已知活性庫 | 抗病毒庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 線粒體靶向庫 | 抗衰老化合物庫 | 臨床期小分子藥物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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