Apocynin NEW
| Price | $50 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-01 |
Product Details
| Product Name: Apocynin | CAS No.: 498-02-2 |
| Purity: 99.98% | Supply Ability: 10g |
| Release date: 2024/11/01 |
Product Introduction
Bioactivity
| 名稱 | Apocynin |
| 描述 | Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM). |
| 體外活性 | Apocynin demonstrates anti-inflammatory activity by reducing neutrophil infiltration, the extent of spinal cord injury, the formation of PAR and nitrotyrosine, and the expression of ICAM-1 and P-selectin. It inhibits the degradation of IκB-α, activation of NF-κB, and apoptosis (as indicated by TUNEL staining, FAS ligand, Bax, and Bcl-2 expression), and the production of pro-inflammatory cytokines (TNF-α and IL-1β) and the activation of MAPK pathways (P-38 and phosphorylated-JNK). The LD50 in mice is 9 g/kg (p.o.). Apocynin is effective in various inflammatory cells and animal models. It attenuates the production of TNF-α and IL-1β, and the expression of iNOS in the lungs of mice treated with carrageenan. Moreover, apocynin offers beneficial effects in mouse models of spinal cord injury. |
| 體內(nèi)活性 | Upon metabolic transformation, Apocynin can inhibit the assembly of NADPH oxidase, possibly due to the production of reactive oxygen species (ROS). It achieves this by inhibiting the serine phosphorylation of p47phox and disrupting its interaction with gp91phox, thereby inactivating NADPH oxidase activity. Furthermore, Apocynin reduces the generation of superoxide (O(2)(-)) in activated macrophages and neutrophils. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (270.81 mM) Ethanol : 16.6 mg/mL (100 mM) |
| 關(guān)鍵字 | Apoptosis | inhibit | NSC2146 | Inhibitor | Apocynin | Autophagy | NSC-2146 |
| 相關(guān)產(chǎn)品 | Stavudine | Sodium 4-phenylbutyrate | L-Ascorbic acid | Hydroxychloroquine | Guanidine hydrochloride | Tributyrin | Paeonol | Naringin |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 經(jīng)典已知活性庫 | 藥物功能重定位化合物庫 | 天然產(chǎn)物庫 | 中藥抗炎分子庫 | 抑制劑庫 | 煙草單體化合物庫 | 已知活性化合物庫 | 古代經(jīng)典名方目錄分子庫 | 藥食同源庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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