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Postion:Product Catalog >API-1
API-1
  • API-1

API-1 NEW

Price $130 $265 $437
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-14

Product Details

Product Name: API-1 CAS No.: 36707-00-3
Purity: 99.07% Supply Ability: 10g
Release date: 2024/11/14

Product Introduction

Bioactivity

名稱API-1
描述API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
體外活性API-1 rapidly and potently reduced the levels of Mcl-1 primarily in API-1-senstive lung cancer cell lines.?Ectopic expression of Mcl-1 protected cells from induction of apoptosis by API-1.?API-1 treatment decreased the half-life of Mcl-1, whereas inhibition of the proteasome with MG132 rescued Mcl-1 reduction induced by API-1.?API-1 decreased Mcl-1 levels accompanied with a rapid increase in Mcl-1 phosphorylation (S159/T163).?Moreover, inhibition of GSK3 inhibited Mcl-1 phosphorylation and reduction induced by API-1 and antagonized the effect of API-1 on induction of apoptosis.
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 22.5 mg/mL (66.71 mM)
關(guān)鍵字TRAIL | Protein kinase B | PKB | NSC-177223 | NSC 177223 | Inhibitor | inhibit | Apoptosis | API-1 | API1 | API 1 | Akt/PKB inhibitor | Akt
相關(guān)產(chǎn)品Ethyl gallate | Oridonin | Capivasertib | SKLB-163 | Scutellarin | Methyl-Hesperidin | Artemisinin | Honokiol | (E)-Akt inhibitor-IV | 2,3-Butanediol | MK-2206 dihydrochloride | AKT Kinase Inhibitor
相關(guān)庫抗肺癌化合物庫 | 糖酵解化合物庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 谷氨酰胺代謝化合物庫 | 自噬庫 | 血管生成庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 細(xì)胞骨架化合物庫 | 抗肝癌化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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