Amiodarone hydrochloride NEW
| Price | $36 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Amiodarone hydrochloride | CAS No.: 19774-82-4 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Amiodarone hydrochloride |
| Description | Amiodarone hydrochloride (Amiodarone HCl) is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance. |
| In vitro | Amiodarone (AM) inhibits the intracellular conversion from thyroxine (T4) to triiodothyronine (T3) via 5'-deiodination (5'DI) without affecting the intracellular conversion from T4 to reverse T3 (rT3).1.25-25 mg/kg Amiodarone in the AV node and in anaesthetized dogs resulted in a decrease in sinus rate, a prolongation of the AV node effective and functional occlusion of the AV node, as well as frequency-dependent conduction delays. 50 mg/kg daily for 3-4 weeks Amiodarone in rabbit ventricular myocytes resulted in a significant reduction in iK and ito current densities without affecting ICA and IK1 densities. |
| In vivo | Amiodarone penetrates deeply into the lipid matrix of the membrane and is released very slowly from cardiac tissue during washout.Amiodarone inhibits fast sodium channels as well as slow calcium channels.Amiodarone also has non-competitive antiarrhythmic effects and regulates thyroid function and phospholipid metabolism.44-88 μM Amiodarone inhibits Vmax of guinea pig papillary muscle without affecting normal hematopoietic stem cells.44-88 μM Amiodarone inhibits Vmax of guinea pig papillary muscle without affecting normal hematopoietic stem cells. Amiodarone inhibits Vmax in papillary muscle without affecting the resting membrane potential, and this Vmax inhibition is potentiated in a frequency- or use-dependent manner as is the case with class I antiarrhythmic drugs.50-88 μM Amiodarone inhibits depolarization-induced spontaneous action potentials (aberrant automaticity) in ventricular myocardium and Purkinje fibers.50-88 μM Amiodarone inhibits depolarization induced action potentials (aberrant automaticity) in human ventricular muscle. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 7.5 mg/mL (11 mM), Sonication is recommended. |
| Keywords | tail | arrhythmias | fibroblasts | KcsA | ventricular | Autophagy | Amiodarone hydrochloride | Potassium Channel | Amiodarone Hydrochloride | Amiodarone | Inhibitor | myofibroblast | antiarrhythmic | hERG | inhibit | supraventricular | benzofuran |
| Inhibitors Related | Stavudine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Gefitinib |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Ion Channel Targeted Library | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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