Product Details
| Product Name:
AM6545 |
CAS No.:
1245626-05-4 |
| Purity:
97.03% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | AM6545 |
| 描述 | AM6545 is a selective and potent peripheral restricted cannabinoid receptor 1 (CB1) antagonist that inhibits the CB2 receptor, ameliorates hypometabolic obesity and improves adipokine secretion in monosodium glutamate-induced obese mice, and may be useful in the study of obesity and diabetes. |
| 體外活性 | METHODS: AM6545 (0.5 mM) was used to treat 3T3-L1 adipocytes to examine possible beiging effects of peripheral CB1R antagonist treatment, and the expression of key beiging markers was examined.
RESULTS: AM6545 significantly increased many genes involved in adipocyte coagulation, including peroxisome proliferator-activated receptor gamma coactivator 1-α (Pgc1α), PR domain containing 16 (Prdm16), and uncoupling protein 1 (Ucp1), cell death-inducing DNA fragmentation factor α-like effector A (Cieda), long-chain fatty acid protein 3 (Elovl3), tumor necrosis factor receptor superfamily member 9 (Cd137), T-box transcription factor ( Tbx1), transmembrane protein 26 (Tmem26), cbp/p300 interacting transactivator 1, fibroid/endoplasmic reticulum calcium 2+-ATPase 2b (Serca2b), ryanodine receptor 2 (Ryr2). [2] |
| 體內(nèi)活性 | METHODS: AM6545 (1 mg/kg, intraperitoneal injection) and CNO (3 mg/kg) were administered to mice, and the discrimination index values ??of NORT in the vagus nerve were observed 48 hours after administration.
RESULTS: AM6545 can improve memory consolidation through an adrenergic mechanism involving vagal afferent nerves. [1] |
| 存儲(chǔ)條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 5 mg/mL (8.99 mM), Sonication is recommended.
|
| 關(guān)鍵字 | AM6545 |
| 相關(guān)產(chǎn)品 | β-Caryophyllene | CB2 modulator 1 | Pregnenolone | Pregnenolone acetate | CB1 antagonist 2 | OMDM-5 | CB2 receptor agonist 2 | 2,3-Butanediol | Drinabant | AM281 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States