Product Details
| Product Name:
Aleglitazar |
CAS No.:
475479-34-6 |
| Purity:
99.42% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Aleglitazar |
| Description | Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes. |
| In vitro | Aleglitazar exhibits species selectivity for PPARα, with EC50 values of 50 nM, 2.26 μM, and 2.34 μM for human, rat, and mouse PPARα, respectively[1]. At concentrations of 0.01-40 μM (12-48 hours), aleglitazar does not significantly increase lactate dehydrogenase (LDH) release at 0.1-20 μM but shows significant increases at 30 μM and 40 μM[2]. Additionally, aleglitazar (0.01-20 μM; 48 hours) decreases hyperglycemia (HG, glucose 25 mM)-induced apoptosis, caspase-3 activity, and cytochrome-C release, while improving cell viability in hyperglycemic conditions[2]. |
| In vivo | Aleglitazar (0.3-3.0 mg/kg; i.p.; daily; for 7 days) exerts beneficial effects on structural and functional outcomes of mild brain ischemia, reduces key aspects of microglia activation including NO production, release of proinflammatory cytokines, migration, and phagocytosis, and attenuates inflammatory responses in the post-ischemic brain[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (102.9 mM)
|
| Keywords | RO-0728804 | RO 0728804 | Aleglitazar | R-1439 | R 1439 |
| Inhibitors Related | PHYTOL | Daidzein | Gemfibrozil | Fenofibrate | Pioglitazone hydrochloride | 5-Aminosalicylic Acid | Naringenin | Fisetin | 2,3-Butanediol | Icariin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$258.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
United States