Alagebrium chloride NEW
| Price | $41 |
| Package | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Alagebrium chloride | CAS No.: 341028-37-3 |
| Purity: 99.65% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Alagebrium chloride |
| 描述 | Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor that has proven effective in reducing systolic blood pressure and providing therapeutic benefits for patients with diastolic. |
| 動(dòng)物實(shí)驗(yàn) | Rat aortic vascular smooth muscle cells (RASMCs) were treated with 1-100 μM of alagebrium added 24 hours before the addition of AGEs.?This in vivo study was done using 8-week-old male rats that were injected intraperitoneally with 80 mg/kg STZ.?Sixteen weeks later, the diabetic rats were treated with 10 mg/kg alagebrium for 4 weeks, after which carotid artery balloon injury was induced.?After 4 weeks, the animals were sacrificed for histological analysis[1]. |
| 體內(nèi)活性 | Alagebrium treatment in diabetic rats significantly inhibits neointimal hyperplasia after carotid balloon injury due to its inhibition of intracellular ROS synthesis, which results in inhibition of RASMCs proliferation[1]. |
| 存儲(chǔ)條件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 65 mg/mL (242.75 mM), Sonication is recommended. |
| 關(guān)鍵字 | Alagebrium chloride | Endogenous Metabolite | ALT-711 | Inhibitor | inhibit | Alagebrium | Alagebrium Chloride | ALT 711 |
| 相關(guān)產(chǎn)品 | Sucrose | Ferulic Acid | Glycerol | Thymidine |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗糖尿病庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 已知活性化合物庫 | 抗高血壓化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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