Adalimumab NEW
| Price | $213 | $449 | $713 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Adalimumab | CAS No.: 331731-18-1 |
| Purity: 99.50% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Adalimumab |
| 描述 | Adalimumab (anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha. |
| 細胞實驗 | Objective: Adalimumab induces apoptosis of THP-1 cells. Concentrations: 10μg/mL. Incubation Time: 6, 12, 18, 24, 30 hours. Method: THP-1 cells (0.5×106) were incubated with anti-FcRI mAb and anti-FcRII mAb, and then cultured with adalimumab, infliximab, huIgG or vehicle (PBS) alone as indicated. LPS (1μg/mL) was added in all culture conditions. Apoptosis was analyzed at different time points by staining with annexin V-FITC and propidium iodide, Apo2.7-PE-conjugated antibody, or 7AAD. |
| 動物實驗 | Objective: The distribution of certolizumab pegol, adalimumab, and infliximab in the inflamed paws of mice with collagen-induced arthritis. Formulation: PBS. Dosages: 2 mg/kg |
| 體外活性 | METHODS: ARPE cells were co-cultured with MT2, TL-Om1 or Jurkat cells and treated with Adalimumab (0.1-10 μg/mL) for 48 h. Supernatants were extracted to measure the levels of inflammatory cytokines using CBA human inflammation cytokine kits. RESULTS: The levels of IL-6, IL-10 and IL-8 production did not change with the addition of Adalimumab. adalimumab decreased tumor necrosis factor (TNF) secretion in a concentration-dependent manner, and TNF was not detected at Adalimumab ≥1.0 μg/mL.[1] METHODS: CD4+ T cells were treated with Adalimumab (1 μg/mL) and aCD3/CD28 mAb for 3 days, then stimulated with PMA/ionomycin in the presence of GolgiStop for 3 h. IL-10 expression was detected using mass spectrometry cytometry (CyTOF). RESULTS: Adalimumab treatment resulted in the induction of IL-10 in multiple CD4+ T cell subsets. [2] |
| 體內活性 | METHODS: To study the effects on the human autosomal recessive RP mouse model, Adalimumab (3 mg/kg) was administered intraperitoneally to rd10 mice, a human autosomal recessive retinitis pigmentosa model, every three days for nine days. RESULTS: Adalimumab reduced photoreceptor cell death by scoring the number of TUNEL-positive cells. adalimumab also improved the antioxidant response by restoring total antioxidant capacity and superoxide dismutase activity. adalimumab normalized the energy and metabolism patterns in the retina of rd10 mice. [3] |
| 存儲條件 | store at low temperature | store at -20°C | Shipping with blue ice. |
| 關鍵字 | Adalimumab |
| 相關產品 | Acetylcysteine | Taxifolin | Acefylline | Glucosamine | Thalidomide | Taurochenodeoxycholic Acid | Apremilast | Pomalidomide | Bergenin | Lenalidomide | Fisetin | Linalool |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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