Acemetacin NEW
| Price | $29 |
| Package | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Acemetacin | CAS No.: 53164-05-9 |
| Purity: 99.26% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Acemetacin |
| 描述 | Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin and a potent non-steroidal anti-inflammatory drug derived from indol-3-acetic acid, with its activity primarily attributed to its active metabolite, indomethacin. In clinical trials, acemetacin shows better gastric tolerability compared to indomethacin. |
| 體外活性 | In rats pre-treated with COX-2 and NOS inhibitors, despite significant inhibition of COX activity, Acemetacin significantly reduces gastrointestinal damage compared to Indomethacin. |
| 體內(nèi)活性 | Acemetacin exerts its anti-inflammatory effect by inhibiting the synthesis of prostaglandins (PG). In inflamed synovial tissue, Acemetacin (10 μM) prevents the release of Prostaglandin E2 (PGE2). It inhibits the release of prostaglandin E2 in joint synovial tissues in vitro. During the incubation of gastric mucosa, the concentration-dependent inhibition of PGE accumulation by Acemetacin is not as effective as Indomethacin, and its reduction effect on gastric 6-keto-PGF1α and thromboxane B2 is also lower than that of Indomethacin. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 77 mg/mL (185.2 mM) Ethanol : 54 mg/mL (129.9 mM) |
| 關(guān)鍵字 | inhibit | Cyclooxygenase | COX | K 708 | Inhibitor | TVX-1322 | Acemetacin | TVX1322 | K708 |
| 相關(guān)產(chǎn)品 | Ibuprofen | Acetaminophen | Diclofenac Potassium | Paradol | Indomethacin sodium hydrate |
| 相關(guān)庫(kù) | 疼痛相關(guān)化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 藥物功能重定位化合物庫(kù) | 抗癌上市藥物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌藥物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $29.00/200mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-14 | |
| $1.90/1KG |
VIP4Y
|
Hebei Chuanghai Biotechnology Co,.LTD
|
2024-08-15 | |
| $0.00/25KG |
VIP5Y
|
Hebei Mojin Biotechnology Co., Ltd
|
2023-08-17 | |
| $66.00/1KG |
Xiamen Wonderful Bio Technology Co., Ltd.
|
2023-07-21 | ||
| $0.00/25kg |
Zhejiang Hengkang Pharmaceutical Co., Ltd.
|
2022-09-01 | ||
| $35.00/1kg |
Hebei baicao biology science and technology co., ltd
|
2022-04-06 | ||
| $13.00/1Kg/Bag |
Hong Kong Tiansheng New Material Trading Co., Ltd
|
2021-12-30 | ||
| $0.00/1Kg/Bag |
VIP4Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2021-09-30 | |
| $10.00/1KG |
VIP6Y
|
Hebei Weibang Biotechnology Co., Ltd
|
2021-09-18 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY