Product Details
| Product Name:
AC1903 |
CAS No.:
831234-13-0 |
| Purity:
98.45% |
Supply Ability:
10g |
| Release date:
2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | AC1903 |
| 描述 | AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss. |
| 動(dòng)物實(shí)驗(yàn) | Twice-daily intraperitoneal injections of AC1903 (50 mg/kg) for 7 days suppressed severe proteinuria in AT1R Tg rats (Advanced)[1] |
| 體內(nèi)活性 | AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.?Chronic administration of AC1903 suppressed severe proteinuria and prevented podocyte loss in a transgenic rat model of FSGS.AC1903 also provided therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.?TRPC5 activity drives disease and that TRPC5 inhibitors may be valuable for the treatment of progressive kidney diseases[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 32.5 mg/mL (107.13 mM)
|
| 關(guān)鍵字 | Inhibitor | glomerulosclerosis | proteinuria | inhibit | TRP Channel | ros | focal segmental | Transient receptor potential channels | AC 1903 | AC1903 | FSGS | kidney disease | podocyte loss | AC-1903 | HEK-293 |
| 相關(guān)產(chǎn)品 | (+)-Camphor | AP 18 | Methyl syringate | Caffeic Acid | Oleoyl Serotonin | (-)-Menthol | Camphor | Pregnenolone | Probenecid | 1,4-Cineole | Methyl salicylate | SKF-96365 hydrochloride |
| 相關(guān)庫(kù) | 疼痛相關(guān)化合物庫(kù) | 神經(jīng)信號(hào)分子庫(kù) | 膜蛋白靶向化合物庫(kù) | 抑制劑庫(kù) | NO PAINS 化合物庫(kù) | 離子通道庫(kù) | 抗癌化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States