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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Abrocitinib
Abrocitinib
  • Abrocitinib

Abrocitinib NEW

Price $77 $109 $170
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: Abrocitinib CAS No.: 1622902-68-4
Purity: 99.91% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱(chēng)Abrocitinib
描述Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).
體外活性Abrocitinib inhibits IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), IFNα-stimulated phosphorylation of STAT3, as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 163, 189 nM, 7.178 μM, respectively.
體內(nèi)活性In the rat adjuvant-induced arthritis model, Abrocitinib (5, 15, 50 mg/kg, p.o., daily for 7 days) significantly reduces paw swelling.
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 120 mg/mL (371.05 mM), Sonication is recommended.
關(guān)鍵字inhibit | PF04965842 | Inhibitor | JAK | Janus kinase | Abrocitinib | PF 04965842
相關(guān)產(chǎn)品Delgocitinib | Deucravacitinib | Fedratinib | RO8191 | Ruxolitinib | Tofacitinib Citrate | CEP-33779 | Ruxolitinib phosphate | JAK-IN-10 | Baricitinib | Tofacitinib | Ritlecitinib
相關(guān)庫(kù)經(jīng)典已知活性庫(kù) | EMA 上市藥物庫(kù) | 抗癌臨床化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 抑制劑庫(kù) | FDA 上市藥物庫(kù) | 抗癌上市藥物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌藥物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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