Ribociclib
Price | $228 |
Package | 200mg |
Min. Order: | 1g |
Supply Ability: | 100g |
Update Time: | 2020-05-17 |
Product Details
Product Name: Ribociclib | CAS No.: 1211441-98-3 |
Min. Order: 1g | Purity: ≥95% |
Supply Ability: 100g | Release date: 2020/05/17 |
Ribociclib, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
Company Profile Introduction
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$36.00/2mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-14 | |
$0.00/1gram |
VIP4Y
|
Zhejiang J&C Biological Technology Co.,Limited
|
2022-02-17 | |
$0.00/25KG |
Hangzhou Huarong Pharm Co., Ltd.
|
2021-09-14 | ||
$15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-06-27 | ||
$2.00/1kg |
VIP7Y
|
Career Henan Chemical Co
|
2018-12-23 |
- Since: 2005-05-19
- Address: Shirley, NY 11967, USA