9-Phenanthrol NEW
| Price | $41 | $53 | $76 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: 9-Phenanthrol | CAS No.: 484-17-3 |
| Purity: 98.72% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | 9-Phenanthrol |
| 描述 | 9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel. |
| 體外活性 | In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50). Channel inhibition was voltage independent. The IC(50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 19 mg/mL (97.82 mM), Sonication is recommended. Ethanol : 9 mg/mL (46.34 mM）, Sonication is recommended. |
| 關(guān)鍵字 | ischemia-reperfusion injury | inhibit | TRPM4 | NSC-50554 | 9Phenanthrol | Inhibitor | NSC 50554 | TRP Channel | 9-Hydroxyphenanthrene | Transient receptor potential channels | 9 Phenanthrol | NSC50554 | 9-Phenanthrol |
| 相關(guān)產(chǎn)品 | (+)-Camphor | Camphor | 1,4-Cineole |
| 相關(guān)庫 | 疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 離子通道庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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