Chlormadinone acetate
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 200kg |
| Update Time: | 2020-01-09 |
Product Details
| Product Name: Chlormadinone acetate | CAS No.: 302-22-7 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 200kg | Release date: 2020/01/09 |
Mary
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Product Name:
Chlormadinone acetate
Synonyms:
6-chloro-17-alpha-acetoxy-4,6-pregnadiene-3,20-dione;6-Chloro-17alpha-acetoxy-4,6-pregnadiene-3,20-dione;6-chloro-17-alpha-hydroxy-delta(sup6)-progesteroneacetate;6-Chloro-17alpha-hydroxy-delta6-progesterone acetate;6-Chloro-17alpha-hydroxypregna-4,6-diene-3,20-dione acetate;6-chloro-17-alpha-hydroxypregna-4,6-diene-3,20-dioneacetate;6-Chloro-17-hydroxypregna-4,6-diene-3,20-dione acetate;6-Chloro-3,20-dioxopregna-4,6-dien-17-yl acetate
CAS:
302-22-7
MF:
C23H29ClO4
MW:
404.93
EINECS:
206-118-0
Product Categories:
Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;SUICALM
Mol File:
302-22-7.mol
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Chlormadinone acetate Chemical Properties
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Melting point
212°C
alpha
D +6° (c = 1 in CHCl3)
Boiling point
512.5±50.0 °C(Predicted)
density
1.1345 (estimate)
storage temp.
-20°C Freezer
form
neat
λmax
285nm(EtOH)(lit.)
Merck
14,2102
BRN
2633614
NIST Chemistry Reference
Chlormadinone acetate(302-22-7)
EPA Substance Registry System
Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-chloro- (302-22-7)
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Safety Information
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Hazard Codes
T
Risk Statements
60-61-40-48
Safety Statements
53-22-36/37/39-45
WGK Germany
3
RTECS
TU3750000
HS Code
29372390
Hazardous Substances Data
302-22-7(Hazardous Substances Data)
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MSDS Information
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Provider
Language
SigmaAldrich
English
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Chlormadinone acetate Usage And Synthesis
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Chemical Properties
Crystalline Solid
Uses
Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive. Progestogen; antineoplastic (hormonal)
Uses
tranquilizer, neuroleptic, alpha adrenergic blocker
Brand name
Gestafortin;Luteran;Ovosiston.
World Health Organization (WHO)
Chlormadinone acetate, a synthetic progestogen, was introduced in 1965 as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, chlormadinone acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and chlormadinone remains available in some countries for contraceptive purposes. In some instances it is indicated for treatment of progesterone deficiency and endometriosis, and of irregular uterine bleeding due to fibroids. (Reference: (WHODI) WHO Drug Information, 84.1, 5, 1984)
Safety Profile
Suspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Human maternal and reproductive effects by ingestion, intramuscular, and possibly other routes: ovary, uterus, cervix, vagina, and fallopian tube changes; menstrual cycle changes or disorders; changes in ferthty; and other unspecified female effects. A human teratogen that causes developmental abnormalities of the endocrine system in the fetus. Experimental teratogenic and reproductive effects. An oral contraceptive. When heated to decomposition it emits toxic fumes of Cl-.
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Chlormadinone acetate Preparation Products And Raw materials
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Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
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