TOLAZAMIDE
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 200kg |
| Update Time: | 2019-12-26 |
Product Details
| Product Name: TOLAZAMIDE | CAS No.: 1156-19-0 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 200kg | Release date: 2019/12/26 |
Mary
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Product Name:
TOLAZAMIDE
Synonyms:
1-(4-Methylphenylsulfonyl)-3-(hexahydro-1H-azepin-1-yl)urea;nsc-70762;tolanase;tolazolamide;tolinase;SALOR-INT L254916-1EA;1-(hexahydro-1-azepinyl)-3-p-tolylsulfonylurea;N-[[(HEXAHYDRO-1H-AZEPINYL)AMINO]CARBONYL]-4-METHYLBENZENESULFONAMIDE
CAS:
1156-19-0
MF:
C14H21N3O3S
MW:
311.4
EINECS:
214-588-3
Product Categories:
Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;TOLINASE
Mol File:
1156-19-0.mol
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TOLAZAMIDE Chemical Properties
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Melting point
162-164°C
Boiling point
300°C (rough estimate)
density
1.2228 (rough estimate)
refractive index
1.6740 (estimate)
storage temp.
Refrigerator
solubility
Very slightly soluble in water; freely soluble in chloroform; soluble in acetone; slightly soluble in ethanol (96%).
pka
3.6(at 25℃)
CAS DataBase Reference
1156-19-0(CAS DataBase Reference)
EPA Substance Registry System
Tolazamide (1156-19-0)
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Safety Information
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Hazard Codes
Xn
Risk Statements
22
Safety Statements
36
WGK Germany
3
RTECS
YT4400000
HS Code
2935904000
Toxicity
LD50 in rats, mice (mg/kg): >5000 orally, 2239 i.p. (Dulin)
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MSDS Information
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Provider
Language
SigmaAldrich
English
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TOLAZAMIDE Usage And Synthesis
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Chemical Properties
White Solid
Uses
Labelled Tolazamide, an antidiabetic.
Uses
Tolazamide
Definition
ChEBI: An N-sulfonylurea that is 1-tosylurea in which a hydrogen attached to the nitrogen at position 3 is replaced by an azepan-1-yl group. A hypoglycemic agent, it is used for the treatment of type 2 diabetes mellitus.
General Description
Tolazamide is N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methylbenzenesulfonamide; or 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea; or 1-(4-methylphenylsulfonyl)-3-(hexahydro-1H-azepin-1-yl)urea (generic).Tolazamide incorporates a fully saturated azepine moietythat is but weakly basic, with a pKa of～3.32 The pKa of thesulfonylurea group lies within the typical range; thus, inareas of the duodenum wherein the pH falls within the rangeof 4 to 5, the uncharged form of the drug is the predominantspecies, and its lipophilicity lends to rapid absorption bypassive diffusion.
General Description
Tolazamide, 1-(hexahydro-1Hazepin-1-yl)-3-(p-tolylsulfonyl)urea (Tolinase), is an analogof tolbutamide and is reported to be effective, in general,under the same circumstances in which tolbutamide is useful.Tolazamide, however, appears to be more potent than tolbutamideand is nearly equal in potency to chlorpropamide. Instudies with radioactive tolazamide, investigators found that85% of an oral dose appeared in the urine as metabolites thatwere more soluble than tolazamide itself.
General Description
White to off-white crystalline powder. Odorless or with a slight odor.
Air & Water Reactions
TOLAZAMIDE may be sensitive to prolonged exposure to air. Insoluble in water.
Reactivity Profile
TOLAZAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). TOLAZAMIDE is incompatible with acids. .
Fire Hazard
Flash point data for TOLAZAMIDE are not available; however, TOLAZAMIDE is probably combustible.
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TOLAZAMIDE Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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