NONACTIN
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | g/kg/Ton |
| Update Time: | 2019-12-26 |
Product Details
| Product Name: NONACTIN | CAS No.: 6833-84-7 |
| EC-No.: 229-911-3 | Min. Order: 1g |
| Purity: ≥98% | Supply Ability: g/kg/Ton |
| Release date: 2019/12/26 | |
| Delivery Time: Prompt | Packaging: Bottle/Durm/Bag |
| Transportation: By air/Bay Sea/Express |
Heidi 0710
Email:heidi@coreychem.com
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NONACTIN Basic information
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Product Name:
NONACTIN
Synonyms:
AMMONIUM IONOPHORE;AMMONIUM IONOPHORE I;WERRAMYCIN A;-(1r*,2r*,5r*,7r*,10s*,11s*,14s*,16s*,19r*,20r*,23r*,25r*,28s*,29s*,32s*,34s*);28))tetracontane-3,12,21,30-tetrone,2,5,11,14,20,23,29,32-octamethyl-2(1r;3584-a;fh-3582-a;n-329-a
CAS:
6833-84-7
MF:
C40H64O12
MW:
736.93
EINECS:
229-911-3
Product Categories:
inhibitor
Mol File:
6833-84-7.mol
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NONACTIN Chemical Properties
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Melting point
147-148°
Boiling point
890.6±65.0 °C(Predicted)
density
1.11-1.15 g/cm3
storage temp.
2-8°C
solubility
chloroform: soluble10mg/mL
form
White to off-white crystalline solid.
color
white to faint yellow
Sensitive
Moisture Sensitive
Merck
13,6709
BRN
76434
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Safety Information
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Hazard Codes
Xi
Safety Statements
22-24/25
WGK Germany
3
RTECS
RH1685000
F
10-21
HS Code
29321900
Toxicity
LD50 intravenous in mouse: 246mg/kg
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MSDS Information
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Provider
Language
SigmaAldrich
English
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NONACTIN Usage And Synthesis
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Chemical Properties
Light yellow powder
Uses
Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.
Biological Activity
Monovalent cation ionophore that displays selectivity for K + and NH 4 + (K + = NH 4 + > Na + > Mg 2+ > Li + >> Ca 2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.
Purification Methods
This macrotetrolide antibiotic crystallises from MeOH as colourless needles and is dried at 90o/20hours/high vacuum. [Cordaz et al. Helv Chim Acta 38 1445 1955, crystal structure: Dobler Helv Chim Acta 55 1371 1972, Gambos et al. Tetrahedron Lett 3391 1975, Beilstein 19/12 V 751.]
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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