Oxaprozin
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1IU |
| Supply Ability: | 100kg |
| Update Time: | 2019-12-25 |
Product Details
| Product Name: Oxaprozin | CAS No.: 21256-18-8 |
| Min. Order: 1IU | Purity: 99% |
| Supply Ability: 100kg | Release date: 2019/12/25 |
| name: Cassie181 |
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Product Name:
Oxaprozin
Synonyms:
4,5-Diphenyl-2-oxazolepropanoic acid, Daypro;2-Oxazolepropanoic acid, 4,5-diphenyl-;Durapro;Oxapro;4,5-Diphenyloxazole-2-propionic acid;Alvo;4,5-Diphenyl-2-oxazolepropanoicacid\Oxaprozin;Oxaprozin,4,5-Diphenyl-2-oxazolepropanoic acid, Daypro
CAS:
21256-18-8
MF:
C18H15NO3
MW:
293.32
EINECS:
244-296-1
Product Categories:
Oxazoles, Isoxazoles & Benzoxazoles;ALINIA;Carboxylic Acids;Oxazoles, Isoxazoles & Benzoxazoles;APIs;Carboxylic Acids;-
Mol File:
21256-18-8.mol
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Oxaprozin Chemical Properties
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Melting point
154 °C
Boiling point
435.17°C (rough estimate)
density
1.2278 (rough estimate)
refractive index
1.5100 (estimate)
pka
4.3(at 25℃)
form
solid
Merck
14,6924
InChIKey
OFPXSFXSNFPTHF-UHFFFAOYSA-N
CAS DataBase Reference
21256-18-8(CAS DataBase Reference)
EPA Substance Registry System
2-Oxazolepropanoic acid, 4,5-diphenyl- (21256-18-8)
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Safety Information
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Hazard Codes
Xn,Xi
Risk Statements
20/21/22-36/37/38
Safety Statements
24/25-36/37/39-36-26
WGK Germany
3
RTECS
RP6990000
Hazard Note
Irritant
HS Code
29349990
Hazardous Substances Data
21256-18-8(Hazardous Substances Data)
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MSDS Information
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Provider
Language
Oxaprozin
English
SigmaAldrich
English
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Oxaprozin Usage And Synthesis
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Abstract
Oxaprozin, also known as Oxaprozinum, (sold under the names: Daypro, Dayrun, Duraprox) is a non-steroidal anti-inflammatory drug (NSAID),used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative.NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.
Taboo
This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.
- Heart disease risk. Oxaprozin belongs to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may increase your risk of heart-related diseases, such as heart attack, heart failure, and stroke. Your risk may be higher if you’re taking it long term, at high doses, or if you already have heart problems or risk factors for heart disease, such as high blood pressure.
- May cause ulcers and stomach bleeding. Oxaprozin can cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may not cause symptoms. Smoking cigarettes or drinking alcohol can make these conditions worse.
- Coronary artery bypass graft surgery. Oxaprozin shouldn’t be used for pain after coronary artery bypass graft surgery. Taking it could increase your risk for a heart attack or stroke.
References
https://en.wikipedia.org/wiki/Oxaprozin
https://www.drugs.com/cdi/oxaprozin.html
http://www.healthline.com/health/oxaprozin/oral-tablet#Highlights1
https://www.drugs.com/cdi/oxaprozin.html
http://www.healthline.com/health/oxaprozin/oral-tablet#Highlights1
Description
Oxaprozin is a non-steroidal antiinflammatory agent indicated for use in various forms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. A long T1/2 allows once/twice daily dosing. Structurally it is somewhat unique, being a 3- substituted, rather than a 2-substituted propionic acid.
Chemical Properties
White Solid
Originator
Wyeth (United Kingdom)
Uses
Oxaprozin is an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).
Uses
antiparasitic
Definition
ChEBI: A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthrit s and rheumatoid arthritis.
Indications
Oxaprozin (Daypro) is approved for the treatment of osteoarthritis and rheumatoid arthritis. Its long halflife allows for once daily dosing.The most frequently reported adverse effects of this drug are nausea, vomiting, and dyspepsia.
Brand name
Daypro (Searle);DURAPROX.
General Description
Oxaprozin, 4,5-diphenyl-2-oxazolepropionic acid (Daypro),differs from the other members of this group in being anarylpropionic acid derivative. It shares the same propertiesand side effects of other members in this group. It is indicatedfor the short- and long-term management of OA andRA, administered as a once-daily dose of 600- to 1,200-mgdose because of its long duration of action.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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