Kaempferol
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 200kg |
| Update Time: | 2019-12-23 |
Product Details
| Product Name: Kaempferol | CAS No.: 520-18-3 |
| Min. Order: 1g | Purity: 99.99% |
| Supply Ability: 200kg | Release date: 2019/12/23 |
Mary
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Product Name:
Kaempferol
Synonyms:
Kaempferol - CAS 520-18-3 - Calbiochem;3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;5,7,4’-trihydroxyflavonol;c.i.75640;campherol;indigoyellow;kaempherol;kampherol
CAS:
520-18-3
MF:
C15H10O6
MW:
286.24
EINECS:
208-287-6
Product Categories:
chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors;-;Flavanols;Tetra-substituted Flavones;Biochemistry;Flavonoids;Natural Plant Extract;Tyrosine Kinase Inhibitors;Signalling
Mol File:
520-18-3.mol
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Kaempferol Chemical Properties
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Melting point
276°C
Boiling point
348.61°C (rough estimate)
density
1.2981 (rough estimate)
refractive index
1.4413 (estimate)
storage temp.
−20°C
solubility
ethanol: 20 mg/mL
pka
6.34±0.40(Predicted)
form
powder
Colour Index
75640
color
yellow
Merck
14,5274
BRN
304401
Stability:
Unstable in Solution
InChIKey
IYRMWMYZSQPJKC-UHFFFAOYSA-N
CAS DataBase Reference
520-18-3(CAS DataBase Reference)
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Safety Information
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Hazard Codes
Xi,T
Risk Statements
36/37/38-68-25
Safety Statements
26-36-45-36/37-36/37/38-22
RIDADR
2811
WGK Germany
-
RTECS
LK9275200
F
8-10-23
HS Code
29329990
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MSDS Information
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Provider
Language
3,4',5,7-Tetrahydroxyflavone
English
SigmaAldrich
English
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Kaempferol Usage And Synthesis
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Chemical Properties
Yellow Solid
Uses
antidepressant, inhibits fatty acid amide hydrolase
Biological Activity
Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca 2+ uniporter (EC 50 = 7 μ M). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro .
Anticancer Research
Kaempferol is one of the secondary metabolites found in some plants, plant-derivedfoods, and traditional medicines. It is a flavonoid compound obtained from someedible plants including grapes, tea, strawberries, broccoli, tomato, cabbage, leek,kale, endive, and beans. It inhibits growth and migration of pancreatic cancer cellsby acting on proto-oncogene tyrosine kinase (Src), ERK1/2, and AKT pathways(Singh et al. 2016a). It is being investigated in pancreatic and lung cancers toevaluate its antiangiogenic, anticancer, and radical scavenging activities. It showsmoderate cytostatic activity in PC3, HeLa, and K562 human cancer cells. It isidentified as aryl hydrocarbon receptor antagonist and acts against ABCG2 (ATP-bindingcassette subfamily G member 2)-mediated multidrug resistance bypreventing the ABCG2 upregulation in esophageal carcinoma. It induces theapoptosis of ovarian cancer cell by activating p53 in intrinsic pathway mechanism.It is an inhibitor of breast cancer resistance protein (BCRP), quinine reductase-2,and a substrate of BCRP (Calderon-Montano et al. 2011; Wang et al. 2012).
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Kaempferol Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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