7,3',4'-Tri-O-methylluteolin NEW
| Price | $89 | $178 | $278 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: 7,3',4'-Tri-O-methylluteolin | CAS No.: 29080-58-8 |
| Purity: 98.66% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | 7,3',4'-Tri-O-methylluteolin |
| 描述 | 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) exhibits anti-inflammatory, antibacterial, and antifungal activities, along with moderate antitrypanosomal activity, having an MIC value of 19.0 μg/mL. |
| 體外活性 | 7,3',4'-Tri-O-methylluteolin significantly inhibited nitric oxide production and demonstrated slight reduction in prostaglandin-E2 level at tested concentrations. The production of pro-inflammatory cytokines, such as TNF-α±, IL-6, and IL-1β, were obviously reduced by 7,3',4'-Tri-O-methylluteolinin a concentration-dependent manner. Moreover, 7,3',4'-Tri-O-methylluteolinsignificantly induced reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level. In addition, we performed molecular docking and molecular dynamic simulations to study the interaction of 7,3',4'-Tri-O-methylluteolinwith inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase-2. Docking study showed its hydrogen bond interactions with key residues in the active site of inducible nitric oxide synthase and cyclooxygenase-2, enlightening its possible binding mode at the molecular level. The results of molecular dynamic simulations showed the stability of complexes and their interactions[1] |
| 存儲條件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 9 mg/mL (27.41 mM) |
| 關鍵字 | COX | TNFR | 7,3',4'TriOmethylluteolin | lipopolysaccharide | Tumor Necrosis Factor Receptor | Inflammation-related diseases | pro-inflammatory cytokines | RAW 264.7 macrophage | Interleukin Related | inhibit | TNF Receptor | Cyclooxygenase | 7,3',4'-Tri-O-methylluteolin | 7,3',4' Tri O methylluteolin | Inhibitor |
| 相關產(chǎn)品 | Sodium Thiocyanate | Bismuth Subsalicylate | Ibuprofen | Acetaminophen | Diclofenac sodium | Glucosamine | Diclofenac Potassium | Apremilast | Paradol | Indomethacin sodium hydrate | Glafenine | Revaprazan hydrochloride |
| 相關庫 | 經(jīng)典已知活性庫 | 中藥單體化合物庫 | 疼痛相關化合物庫 | 抗真菌庫 | 中藥抗炎分子庫 | 抗感染天然產(chǎn)物庫 | 已知活性化合物庫 | 古代經(jīng)典名方目錄分子庫 | 藥食同源庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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