Cefatrizine
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | KG/T |
| Update Time: | 2019-12-20 |
Product Details
| Product Name: Cefatrizine | CAS No.: 51627-14-6 |
| EC-No.: 257-324-2 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: KG/T |
| Release date: 2019/12/20 |
heidi51
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Product Name:
Cefatrizine
Synonyms:
cephatriazine;eta(r)))-;l)acetyl)amino)-8-oxo-3-((1h-1,2,3-triazol-4-ylthio)methyl)-,(6r-(6-alpha,7-b;s640p;Cephathiamidine;CEFATRIZINE IMPURITY A7-AMINO-(6R,7R)-3-[(2H-1,2,3-TRIAZOL-4-YL)SULFANYL]-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.O]OCT-2-ENE-2-CARBOXYLIC ACID(7-ACA TRIAZOLE) EPC(CRM STANDARD);CEFATRIZINE;CEFATRIZINE PROPYLENE GLYCOL
CAS:
51627-14-6
MF:
C18H18N6O5S2
MW:
462.51
EINECS:
257-324-2
Product Categories:
-
Mol File:
51627-14-6.mol
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Cefatrizine Chemical Properties
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Boiling point
948.1±65.0 °C(Predicted)
density
1.3806 (rough estimate)
refractive index
1.7000 (estimate)
pka
2?+-.0.50(Predicted)
CAS DataBase Reference
51627-14-6(CAS DataBase Reference)
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Safety Information
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Toxicity
LD50 in male, female mice, male, female rats (mg/kg): 6880, 6410, 4325, 4325 i.p. (Matsuzaki)
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MSDS Information
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Cefatrizine Usage And Synthesis
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Uses
Antidepressant, Selective serotonin reuptake inhibitor
Definition
ChEBI: A cephalosporin compound having (1H-1,2,3-triazol-4-ylsulfanyl)methyl and [(2R)-2-amino-2-(4-hydroxyphenyl)]acetamido side-groups. An antibacterial drug first prepared in the 1970s, it has more recently been found to be n inhibitor of eukaryotic elongation factor-2 kinase (eEF2K), which is known to regulate apoptosis, autophagy and ER stress in many types of human cancers.
Antimicrobial activity
A semisynthetic cephalosporin formulated for oral use. The spectrum is similar to that of cefalexin but it is more active against H. influenzae. Wide strain variations in susceptibility have been reported.
It is only partially absorbed when given by mouth. A 500 mg oral dose achieves a concentration of c. 6 mg/L after 1–2 h. The normal half-life of 2.5 h is extended to 5.5 h in end-stage renal failure. Distribution resembles that of cefalexin. It crosses the placenta readily. Plasma protein binding is 40–60%.
Urinary recovery in 6 h is 35% of an oral dose, producing urinary levels of 50–1500 mg/L. It is presumed that the remainder is metabolized, but no metabolites have been identified.
Apart from some mild diarrhea, it is well tolerated. It is available in Japan.
It is only partially absorbed when given by mouth. A 500 mg oral dose achieves a concentration of c. 6 mg/L after 1–2 h. The normal half-life of 2.5 h is extended to 5.5 h in end-stage renal failure. Distribution resembles that of cefalexin. It crosses the placenta readily. Plasma protein binding is 40–60%.
Urinary recovery in 6 h is 35% of an oral dose, producing urinary levels of 50–1500 mg/L. It is presumed that the remainder is metabolized, but no metabolites have been identified.
Apart from some mild diarrhea, it is well tolerated. It is available in Japan.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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