METHYL 4-AMINOSALICYLATE
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | Customized |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: METHYL 4-AMINOSALICYLATE | CAS No.: 4136-97-4 |
| EC-No.: 223-958-3 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: Customized |
| Release date: 2019/07/06 |
SP476
| METHYL 4-AMINOSALICYLATE Basic information |
| Product Name: | METHYL 4-AMINOSALICYLATE |
| Synonyms: | Methyl 4-aminosalicylate, 3-Hydroxy-4-(methoxycarbonyl)aniline, 5-Amino-2-(methoxycarbonyl)phenol;Methyl 4-amino-2-hydroxybenzoate 97%;Benzoic acid,4-aMino-2-hydroxy-, Methyl ester;Methyl 4-aMino-2-hydroxybenzenecarboxylate, >95%;4-AMINOSALICYLATE;METHYL 4-AMINO-2-HYDROXYBENZOATE;P-AMINO METHYL SALICYLATE;4-amino-2-hydroxy-benzoicacimethylester |
| CAS: | 4136-97-4 |
| MF: | C8H9NO3 |
| MW: | 167.16 |
| EINECS: | 223-958-3 |
| Product Categories: | - |
| Mol File: | 4136-97-4.mol |
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| METHYL 4-AMINOSALICYLATE Chemical Properties |
| Melting point | 120-123°C |
| density | 1.305±0.06 g/cm3 (20 ºC 760 Torr) |
| form | Powder |
| Water Solubility | Slightly soluble in water. |
| λmax | 254nm(lit.) |
| CAS DataBase Reference | 4136-97-4(CAS DataBase Reference) |
| Safety Information |
| RTECS | VO1683000 |
| HazardClass | IRRITANT |
| MSDS Information |
| METHYL 4-AMINOSALICYLATE Usage And Synthesis |
| Enzyme inhibitor | This aromatic acid (FWfree-acid = 153.14 g/mol: CAS 2066-89-9; Abbreviation: PAS), also known by the trade name Paser? as well as 4- aminosalicylic acid or p-aminosalicylic acid, is an analogue of p- aminobenzoate, an essential intermediate in the bacterial folate synthesis. PAS potently inhibits the growth of Mycobacterium bovi, M. smegmatis, and M. tuberculosis. It is also used for the treatment of such inflammatory bowel diseases as ulcerative colitis and Crohn's disease, most likely by inhibiting NF-kB. Primary Mode of Antimicrobial Action: Although in use clinically for over 60 years, p-aminosalicylate’s inhibitory mechanism had proved elusive. Recent studies, however, demonstrated that PAS is prodrug, one that targets dihydrofolate reductase, or DHFR. PAS is first converted by dihydropteroate synthase (DHPS) a nd dihydrofolate synthase (DHFS) to a hydroxyl-dihydrofolate antimetabolite, which in turn inhibits DHFR. PAS is about as efficient a DHPS substrate as its natural substrate pABA, and inhibition of DHPS or mutation in DHFS prevents the formation of the antimetabolite and confers resistance to PAS. |
| METHYL 4-AMINOSALICYLATE Preparation Products And Raw materials |
| Preparation Products | Methyl 4-acetamido-2-methoxybenzoate-->4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide-->METHYL 4-ACETAMIDO-2-METHOXYBENZOAT |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com