6-(γ,γ-Dimethylallylamino)purine NEW
| Price | $41 | $67 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 6-(γ,γ-Dimethylallylamino)purine | CAS No.: 2365-40-4 |
| Purity: 99.07% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 6-(γ,γ-Dimethylallylamino)purine |
| Description | 6-(γ,γ-Dimethylallylamino)purine (Triacanthine), which is a plant growth substance, shows hypertensive and antitumor activity, also cardiotonic, antispasmodic and a respiratory analeptic. |
| In vitro | 6-(γ,γ-Dimethylallylamino)purinee significantly inhibited EJ cell proliferation (IC50 600μM). Flow cytometry analysis revealed that cells were arrested in the G1 phase, and apoptotic cells accumulated in the sub-G1 phase in a dose-dependent manner. 6-(γ,γ-Dimethylallylamino)purinee inhibited the G1-S transition by deterring complex formation between cyclin-dependent kinases and cyclins, thereby up-regulating cell cycle inhibitors p21WAF1 and p27KIP1. |
| In vivo | In an in vivo study, 6-(γ,γ-Dimethylallylamino)purinee significantly limited growth of xenografted tumors. Interestingly, while cisplatin resulted in significant weight loss after a 5-mg/kg dose, 6-(γ,γ-Dimethylallylamino)purinee did not cause weight loss, behavioral abnormalities, altered biochemical parameters, or tissue staining. A single oral dose acute-toxicity test (6-(γ,γ-Dimethylallylamino)purinee 2,000mg/kg) produced no adverse cytotoxic effects via blood biochemical tests and tissue-organ staining. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 2.03 mg/mL (10 mM), Sonication is recommended. |
| Keywords | 6-(r,r-Dimethylallylamino)purine | 6-(γ,γ-Dimethylallylamino)purine | 6(γ,γDimethylallylamino)purine | inhibit | 6 (γ,γ Dimethylallylamino)purine | Inhibitor | 6-(gamma,gamma-Dimethylallylamino)purine |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Pesticide Compound Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Natural Product Library | Tobacco Monomer Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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