Edoxaban intermediate properties Melting point 199.0to203.0 ° C Boiling point 175 ℃ [at101325Pa] Storage conditions Undernertgas (nitroorArgon) at2-8 ° C Solubility AqueousAcid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (VerySlig form Solid color PaleBeigotoLightBrown stability Hygrosopic Yidoxaban intermediate use and synthesis method use 5-methyl-4,5,6,7-tetrahydrothiazole [5,4-c] pyridine-2-carboxylic acid hydrochloride as a reagent for the synthesis of N - (2-acylaminobenzyl or 2-acylaminoheterocyclic methyl) thiophene-2 - carboxamide derivatives as antithrombotic agents. It can also be used as a reagent for synthesizing diamine derivatives (FXa inhibitors). 5-methyl-4,5,6,7-tetrahydrothiazolo [5,4-c] pyridin-2-carboxylic acid hydrochloride is the intermediate of Edoxaban (E555520). Usage The intermediate of Yidoxaban can be used as impurity reference substance, and also used for drug declaration and detection.