5-Ethynyl-2'-deoxyuridine NEW
| Price | $33 | $53 | $173 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 5-Ethynyl-2'-deoxyuridine | CAS No.: 61135-33-9 |
| Purity: 98.1% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 5-Ethynyl-2'-deoxyuridine |
| Description | 5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].Like 5-bromo-2’-deoxyuridine (BrdU), EdU is incorporated into DNA during active DNA synthesis. It can then be detected using a fluorescent azide probe and copper catalysis using 1,3-dipolar cycloaddition.Modified nucleosides, including EdU, can be cytotoxic when added to cells for prolonged periods[2].5-Ethynyl-2'-deoxyuridine (EdU) staining is a fast, sensitive and reproducible method to study cell proliferation in the central nervous system[3] |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 8 mg/mL (31.72 mM), Sonication is recommended. DMSO : 120 mg/mL (475.77 mM), Sonication is recommended. |
| Keywords | 5 Ethynyl 2' deoxyuridine | PROTAC Linkers | inhibit | Inhibitor | 5Ethynyl2'deoxyuridine | 5-Ethynyl-2'-deoxyuridine |
| Inhibitors Related | N-Boc-4-pentyne-1-amine | Diethylene glycol bis(p-toluenesulfonate) | 6-Maleimidocapronic acid | Fmoc-8-amino-3,6-dioxaoctanoic acid | Bis-Tos-PEG4 | Boc-NH-PEG4-CH2COOH | 11-Aminoundecanoic acid | 1,3-Dibromo-5,5-dimethylhydantoin | 1-Bromo-6-chlorohexane | Ac4ManNAz |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Human Metabolite Library | Nucleotide Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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