Nelarabine
| Price | $1 |
| Package | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | Customized |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: Nelarabine | CAS No.: 121032-29-9 |
| EC-No.: 1806241-263-5 | Min. Order: 1kg |
| Purity: 99% | Supply Ability: Customized |
| Release date: 2019/07/06 |
SP237
| Nelarabine Basic information |
| Physical properties Developed by GlaxoSmithKline Pharmacology and pharmacokinetics Clinical trials Usage and dosage Note |
| Product Name: | Nelarabine |
| Synonyms: | NELARABINE;Nelzarabine [USAN];Nelzarabine;9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine;(2R,3R,4S,5R)-2-(2-aMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)-tetrahydrofuran-3,4-diol;Nelarabine (Arranon);506u;9-β-D-Arabinofuranosyl-6-Methoxy-9H-purin-2-aMine |
| CAS: | 121032-29-9 |
| MF: | C11H15N5O5 |
| MW: | 297.27 |
| EINECS: | 1806241-263-5 |
| Product Categories: | Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;5g,10g,25g,100g;ARRANON;Anti-cancer&immunity;API;Inhibitors |
| Mol File: | 121032-29-9.mol |
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| Nelarabine Chemical Properties |
| Melting point | 209-217° |
| alpha | D20 +55.9° (c = 0.27 in DMF) |
| CAS DataBase Reference | 121032-29-9(CAS DataBase Reference) |
| Safety Information |
| MSDS Information |
| Nelarabine Usage And Synthesis |
| Physical properties | White or almost white crystalline powder. This product is slightly soluble in water, the solubility in water is about 8-9mg/ml (25 ℃, PH = 4~10). |
| Developed by GlaxoSmithKline | Nelarabine is a prodrug for deoxyguanosine analogue ——9-beta-D-arabinofuranosyl guanine (ara-G). Nelarabine demethylates in the role of adenosine deaminase (ADA) and turns into ara-G. Then, It turns into active ara-G triphosphate (ara-GTP) in the role of the deoxyguanosine kinase and deoxycytidine kinase and under the action of the monophosphorylation pathway. Ara-GTP can accumulate in leukemia cells, and bind to DNA to inhibit DNA synthesis, and accelerate leukemia cell death. In addition, the anti-cancer mechanism of Nelarabine may also be related to its cytotoxicity and somatic toxicity. Nelarabine was first successfully developed by GlaxoSmithKline. On October 28, 2005 under the approval of the US Food and Drug Administration, it became a new drug for curing T-cell acute lymphoblastic leukemia (T-ALL) and T-Cells lymphoblasticlymphoma (T-LBL) which are resistant to at least two types of chemotherapy regimens or relapsed after initial treatment. This new drug officially listed in the United States in 2006. This product didn’t apply for patent and administrative protection in China, so the development of this product does not exist intellectual property issues. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com