Chinese name: Levamisole hydrochloride

English name :Levamisole hydrochloride

CAS:16595-80-5

EINECS number :240-654-6

Molecular formula :C11H13ClN2S

MDL number :MFCD00005536

Molecular weight :240.75

Appearance: White to light yellow crystalline powder, odorless, bitter taste. Melting point 227-229℃. Soluble in water, methanol, ethanol and glycerol, slightly soluble in chloroform, ether; Insoluble in acetone. It is stable under acidic conditions and easy to decompose and fail under alkaline conditions.

Melting point :266-267 °C(lit.)

Specific rotation :-128 o (c=5, H2O)

Refractive index :-126 ° (C=1, H2O)

Flash point :9℃

Storage conditions :0-6°C

Solubility :Freely soluble in water, soluble in ethanol (96 per cent), slightly soluble in methylene chloride.

Form: crystalline powder

Color: White to almost white

Water solubility :210 g/L (20 oC)

Merck:5459

BRN:4358988

BCS Class:3/1

Stability: hygroscopicity

InChI:InChI=1/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10; 5, 10 H/h1 -, 6-8 h2. 1H/t10-; /s3

InChIKey:LAZPBGZRMVRFKY-HNCPQSOCSA-N

SMILES:[C@H]1(N=C2SCCN2C1)C1=CC=CC=C1.Cl |&1:0,r|

LogP:1.845 (est)

category

Feed additive: insect repellent health care agent

Use 1

It is suitable for eliminating roundworm, hookworm and Malayan filaria infection

Use 2

As a deworming drug, it is suitable for the treatment of animal roundworm and hookworm.

Preparation method

Method one

The salt was obtained from racemic tetraimidazole by separation, alkali analysis and acidification.

The dibenzoyl-D-tartrate anhydride was boiled in water for 40min, and then neutralized with sodium hydroxide solution to PH7.5, and racemic tetraimidazole was added. Levamisole is precipitated with dibenzoyltartaric acid as a salt. After separation, add sodium hydroxide solution to PH=9 to decompose levamisole. Then dissolved in dilute hydrochloric acid solution, decolorized by activated carbon, concentrated and nearly dry filtrate, added acetone cooling to 0℃ crystallization. Levamisole hydrochloride was obtained by filtration and drying.