2-Amino-5-bromo-3-iodopyridine NEW
Price | $15 |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 10000kg/month |
Update Time: | 2024-05-23 |
Product Details
Product Name: 2-Amino-5-bromo-3-iodopyridine | CAS No.: 381233-96-1 |
Min. Order: 1kg | Purity: 99.9% |
Supply Ability: 10000kg/month | Release date: 2024/05/23 |
Chinese name: 2-amino-3-iodo-5-bromopyridine
English name: 2-AMINO-5-BROMO-3-IODOPYRIDINE
CAS: 381233-96-1
Molecular formula: C5H4BrIN2
MDL number: MFCD06659000
Molecular weight: 298.91
Melting point: 111-112°C
Boiling point: 308.2±42.0 °C(Predicted)
Density: 2.426± 0.06g /cm3(Predicted)
Storage conditions: Keep in dark place,Sealed in dry,Room Temperature
Acidity coefficient (pKa) : 2.25±0.49(Predicted)
Sensitive photosensitivity
InChIKey: XPERZSKJGNUSHI-UHFFFAOYSA-N
Apply
2-amino-3-iodo-5-bromopyridine can be used to synthesize tyrosine kinase inhibitors to treat cancer or prevent the spread of cancer cells, and CRAC inhibitors to treat autoimmune and inflammatory diseases.
preparation
Add 38ml of mixed solvent ethyl acetate and ethanol, and 15ml ethyl acetate into a 100ml round-bottom single-mouth flask. Insert a thermometer, start a magnetic stirrers, add 17.4g of 2-amino-5-bromopyridinium, add 39.38g of n-iodosuccinimide, and stir continuously at 25℃ for 18 hours. TLC and GC determined that the reaction of 2-amino-5-bromopyridine was complete. The product was recrystallized with a mixture of n-hexane and ethanol to obtain 2-amino-3-iodo-5-bromopyridine. After drying, the calculated yield was 80.3%, and the purity was 97.2%. Nuclear magnetic resonance analysis: 1HMR(CDCl3)400MHz:δ7.98 (s,1H); δ7.66(s,1H); Delta 4.96 (bs, 2 h
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