4 - Piperazin - 1 - ylbenzaldehyde (CAS No.: 27913 - 98 - 0) —— In-Depth Analysis of a Multifunctional Organic Intermediate

I. Basic Information and Physicochemical Properties
(1) Core Chemical Parameters

• Chinese Name:
  

• English Name: 4 - (Piperazin - 1 - yl)benzaldehyde

• CAS No.: 27913 - 98 - 0

• Molecular Formula: $C_{11}{H}_{14}{N}_{2}O$

• Molecular Weight: 190.24

• Appearance: White to light-yellow crystalline powder

(2) Physicochemical Properties

• Melting Point: 95 - 97℃

• Boiling Point: 350 - 352℃ (atmospheric pressure)

• Density: 1.14 g/cm3

• Solubility: Slightly soluble in water; highly soluble in common organic solvents (e.g., ethanol, acetone, chloroform).

• Chemical Characteristics:

• Contains an aldehyde group (-CHO), enabling oxidation to carboxylic acids and condensation with amines to form Schiff bases.

• Nitrogen atoms in the piperazine ring exhibit basicity, reacting with acids to form salts and participating in nucleophilic substitution reactions.

II. Upstream and Downstream Industrial Chain Analysis
(1) Upstream Raw Materials and Synthesis Process

• Key Raw Materials: Piperazine, 4 - fluorobenzaldehyde

• Main Synthetic Route:

• React piperazine with 4 - fluorobenzaldehyde in solvents like N,N-dimethylformamide (DMF), using potassium carbonate as a base.

• Nucleophilic substitution occurs, replacing fluorine with piperazine’s nitrogen to form 4 - piperazin - 1 - ylbenzaldehyde.

• Purification via extraction, washing, drying, and recrystallization yields a product with ~70% - 80% purity.

(2) Downstream Products and Derivatives

• Pharmaceutical Applications:

• Key intermediate for antidepressants, antipsychotics, and antibacterial drugs. Derivatives modulate neurotransmitters or target specific receptors.

• Materials Science:

• Acts as a ligand in metal-organic complexes for catalysis or fluorescent materials.

• Enables synthesis of polymers with optical or conductive properties.

III. Key Application Areas
(1) Pharmaceutical R&D and Innovative Drugs

• Antidepressants: Derivatives regulate serotonin and dopamine levels, improving mood with minimal side effects in clinical trials.

• Antipsychotics: Targets dopamine receptors to manage schizophrenia symptoms, showing efficacy in animal models.

(2) Materials Science and Advanced Technologies

• Metal-Organic Complexes: Forms fluorescent complexes for sensors detecting specific molecules or ions.

• Polymers: Enhances charge transport in conductive polymers when incorporated into structures.

IV. Technological Advantages and Market Dynamics
(1) Technological Advantages

• Simple synthesis, readily available raw materials, mild reaction conditions.

• Optimized solvents and bases improve yield/purity. Aldehyde and piperazine groups enable diverse functionalizations.

(2) Market Trends

• Growing demand in pharmaceuticals and materials science.

• 2024 Global Market Size: ~$15 million USD, projected to grow 10% - 12% annually.

• Key producers in China, USA, and Europe. Chinese firms gain market share via cost efficiency and technological advancements.

V. Safety and Storage Recommendations
(1) Hazards

• Irritating to eyes, skin, and respiratory tract. Avoid contact; wear protective gear (goggles, gloves, respirator). Toxic; avoid ingestion.

(2) Storage Conditions

• Store in cool, dry, ventilated areas, away from heat/ignition sources. Keep sealed, separated from oxidizers and acids.

VI. SEO Optimization Strategy
(1) Keyword Placement

• Core Keywords: 4 - piperazin - 1 - ylbenzaldehyde, 27913 - 98 - 0, benzaldehyde intermediate

• Long-Tail Keywords:

• 4 - piperazin - 1 - ylbenzaldehyde synthesis process

• Pharmaceutical applications of 4 - piperazin - 1 - ylbenzaldehyde

• Market outlook for 4 - piperazin - 1 - ylbenzaldehyde

Translation formatted to retain original structure and technical accuracy while adapting to English terminology conventions.