4-Phenylbutyric acid NEW
| Price | $41 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: 4-Phenylbutyric acid | CAS No.: 1821-12-1 |
| Purity: 99.76% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | 4-Phenylbutyric acid |
| 描述 | 4-Phenylbutyric acid (Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and an endoplasmic reticulum stress (ERS) inhibitor. 4-Phenylbutyric acid can be used to treat urea cycle disorders. |
| 體外活性 | METHODS: ERp57 KO and control cells were treated with 4-Phenylbutyric acid (50 mM) and protein expression levels were detected by Immunoblot analysis. RESULTS: Levels of ER stress marker proteins BiP, Chop and IRE1 were increased in ERp57 KO cells compared to control cells, indicating higher levels of ER stress in the absence of ERp57. 50 mM 4-Phenylbutyric acid treatment was effective in ERp57 KO cells and reduced protein levels of all three ER stress markers. protein levels of all three ER stress markers. In the case of IRE1, ER stress proteins were even reduced below the levels of control cells. [1] METHODS: A549 cells and primary nasal epithelial cells were treated with 4-Phenylbutyric acid (0-20 mM) for 72 h. Cell viability was measured by MTT assay. RESULTS: Cells were examined after treatment with 4-Phenylbutyric acid concentrations ranging from 0-20 mM, and cell survival was not affected below 10 mM. [2] |
| 體內(nèi)活性 | METHODS: To study the effects on obese mice, 4-Phenylbutyric acid (120 mg/kg) was administered intraperitoneally to KK-Ay mice fed Lieber-DeCarli diet (5% EtOH) once daily for ten days. On day 11, a single dose of EtOH (4 g/kg) was administered by gavage. RESULTS: In an obese mouse model, chronic overdose of EtOH induced massive ER stress-related oxidative stress and liver injury through dysregulation of unfolded protein responses. 4-Phenylbutyric acid ameliorated the liver injury induced by chronic addition of overdose of EtOH by decreasing ER and oxidative stress after overdose of EtOH. [3] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (304.51 mM) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 12.5 mg/mL (76.13 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. |
| 關(guān)鍵字 | 4-PBA | 4Phenylbutyric acid | 4-Phenylbutyric acid | Virus Protease | inhibit | Histone deacetylases | HDAC | Inhibitor | 4 Phenylbutyric acid |
| 相關(guān)產(chǎn)品 | EIDD-1931 | Phenytoin sodium | Valproic acid sodium salt | Panobinostat | Sodium 4-phenylbutyrate | Anthraquinone | 2-Phenylethanol | Curcumin | (-)-α-Pinene | Theophylline |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗癌臨床化合物庫 | 抗病毒庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗癌上市藥物庫 | 抗衰老化合物庫 | 古代經(jīng)典名方目錄分子庫 | 抗癌藥物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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