4'-bromo-Resveratrol NEW
| Price | $68 | $109 | $228 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: 4'-bromo-Resveratrol | CAS No.: 1224713-90-9 |
| Purity: 99.4% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | 4'-bromo-Resveratrol |
| 描述 | 4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3) |
| 體外活性 | 4'-BR treatment of melanoma cells resulted in (a) decrease in proliferation and clonogenic survival;?(b) induction of apoptosis accompanied by a decrease in procaspase-3, procaspase-8, and increase in the cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP);?(c) marked downregulation of proliferating cell nuclear antigen (PCNA);?and (d) inhibition of melanoma cell migration.?Further, 4'-BR caused a G0/G1 phase arrest of melanoma cells that was accompanied by an increase in WAF-1/P21 and decrease in Cyclin D1/Cyclin-dependent kinase 6 protein levels.?4'-BR causes a decrease in lactate production, glucose uptake, and NAD+ /NADH ratio.?These responses were accompanied by downregulation in lactate dehydrogenase A and glucose transporter 1 in melanoma cells.[1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 30 mg/mL (103.04 mM) |
| 關(guān)鍵字 | melanoma cell growth | Apoptosis | Sirtuin-3 | Sirtuin-1 | 4' bromo Resveratrol | inhibit | Inhibitor | cell cycle | Sirtuin | 4′‐BR | 4'bromoResveratrol | mitochondrial metabolic reprogramming | antiproliferative | 4'-bromo-Resveratrol |
| 相關(guān)產(chǎn)品 | JGB1741 | Sirtinol | Dihydrocoumarin | Nicotinamide riboside chloride | Resveratrol | SRT 2104 | Nicotinamide riboside | Fisetin | 3-TYP | Nicotinamide |
| 相關(guān)庫(kù) | 組蛋白修飾化合物庫(kù) | DNA 損傷和修復(fù)分子庫(kù) | 經(jīng)典已知活性庫(kù) | 表觀遺傳庫(kù) | 抑制劑庫(kù) | NO PAINS 化合物庫(kù) | 線粒體靶向庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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