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Postion:Product Catalog >Pharmaceutical intermediates>Heterocyclic compound>Pyrimidines>Aminopyrimidine>4-Aminopyrazolo[3,4-d]pyrimidine
4-Aminopyrazolo[3,4-d]pyrimidine
  • 4-Aminopyrazolo[3,4-d]pyrimidine
  • 4-Aminopyrazolo[3,4-d]pyrimidine

4-Aminopyrazolo[3,4-d]pyrimidine NEW

Price $5 $0.1
Package 1KG 1000KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-04-09

Product Details

Product Name: 4-Aminopyrazolo[3,4-d]pyrimidine CAS No.: 2380-63-4
Min. Order: 1KG Purity: 98%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/04/09
Lead time: In stock, ready for shipment Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea Delivery: Manufacturer, advantage product
COA, MSDS: Manufacturer, advantage product Name: Tina

 1. Materials information

Names

Name4-Aminopyrazolo[3,4-d]pyrimidine
SynonymMore Synonyms

 4-Aminopyrazolo[3,4-d]pyrimidine Biological Activity

DescriptionPyrazoloadenine is a potent RET (REarranged during Transfection) lung cancer oncoprotein inhibitor. Pyrazoloadenine shows anticancer activity[1][2].
Related Catalog
Research Areas >> Cancer
In VitroPyrazoloadenine inhibits a wide range of protein kinases such as BTK (Bruton’s tyrosine kinase), CDK1/2 (cyclin-dependent kinase 1/2), Src kinase, and RIPK1 (receptor-interacting protein kinase)[1].

 Chemical & Physical Properties

Density1.612g/cm3
Boiling Point431.1oC at 760mmHg
Melting Point>325 °C(lit.)
Molecular FormulaC5H5N5
Molecular Weight193.671
Flash Point244.4oC
Exact Mass193.086960
PSA80.48000
LogP0.51630
Storage condition-20°C Freezer

 MSDS

4-Aminopyrazolo[3,4-d]pyrimidine MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • UR0717000

  • CHEMICAL NAME :

  • 1H-Pyrazolo(3,4-d)pyrimidine, 4-amino-

  • CAS REGISTRY NUMBER :

  • 2380-63-4

  • BEILSTEIN REFERENCE NO. :

  • 0005824

  • LAST UPDATED :

  • 199701

  • DATA ITEMS CITED :

  • 9

  • MOLECULAR FORMULA :

  • C5-H5-N5

  • MOLECULAR WEIGHT :

  • 135.15

  • WISWESSER LINE NOTATION :

  • T56 BMN GN INJ FZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 141 mg/kg

  • TOXIC EFFECTS :

  • Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 228 mg/kg

  • TOXIC EFFECTS :

  • Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 180 mg/kg

  • TOXIC EFFECTS :

  • Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 181 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD10 - Lethal Dose

  • ROUTE OF EXPOSURE :

  • Unreported

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 15 mg/kg

  • TOXIC EFFECTS :

  • Liver - other changes

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Mammal - cat

  • DOSE/DURATION :

  • 100 mg/kg

  • TOXIC EFFECTS :

  • Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - urine volume increased

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Mammal - dog

  • DOSE/DURATION :

  • 22500 mg/kg/9D-I

  • TOXIC EFFECTS :

  • Liver - fatty liver degeneration Blood - changes in bone marrow (not otherwise specified) Blood - changes in platelet count

MUTATION DATA

  • TYPE OF TEST :

  • DNA inhibition

  • TEST SYSTEM :

  • Rodent - mouse Ascites tumor

  • DOSE/DURATION :

  • 5 umol/L

  • REFERENCE :

  • ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 48,319,1967

 Safety Information

SymbolArticle illustration
GHS06
Signal WordDanger
Hazard StatementsH301-H315-H319-H335
Precautionary StatementsP261-P301 + P310-P305 + P351 + P338
Personal Protective EquipmentEyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard CodesT:Toxic;
Risk PhrasesR23/24/25;R36/37/38
Safety PhrasesS26-S36/37/39-S45-S22
RIDADRUN 2811 6.1/PG 3
WGK Germany3
RTECSUR0717000
Packaging GroupIII
Hazard Class6.1
HS Code2933990090

 Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles30

More Articles
Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus.

J. Neurosci. 35(11) , 4540-51, (2015)

The dorsal cochlear nucleus (DCN) is one of the first stations within the central auditory pathway where the basic computations underlying sound localization are initiated and heightened activity in t...

Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.

J. Clin. Invest. 124(6) , 2585-98, (2014)

Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER stress-associated transcri...

Spectroscopic, electronic structure and natural bond analysis of 2-aminopyrimidine and 4-aminopyrazolo[3,4-d]pyrimidine: a comparative study.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96 , 226-41, (2012)

The FTIR and FT-Raman spectra of 2-aminopyrimidine (2-AP) and 4-aminopyrazolo[3,4-d]pyrimidine (4-APP) has been recorded in the region 4000-400 and 3500-100 cm(-1), respectively. The tautomeric stabil...

 Synonyms

Methyl 3-piperidinylacetate hydrochloride (1:1)
7-deaza-8-aza-adenine
8-aza-7-deazaadenine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine
1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
EINECS 219-174-6
pyrazolo[3,4-d]pyrimidin-4-amine
Pyrazoloadenine
Aminopurinol
4-aminopyrazolo-(3,4-d)pyrimidine
4-aminopyrazolo[5,4-d]pyrimidine
4-Aminopyrazolopyrimidine
1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine 4-Amino-1H-pyrazolo[3,4-d]pyrimidine
Pyrazolo[3,4-d]pyrimidin-4-amin
4-app
ADENINE ANTIMETABOLITE
MFCD00005688
3-Piperidineacetic acid, methyl ester, hydrochloride (1:1)
4-AMINOPYRAZOLO{3,4-D}PYRIMIDINE
1(H)-4-amine-pyrazolo[3,4-d]pyrimidine
4-Amino pyrazolo[3,4-d]pyrimidine


2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration


  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 13213167925

WhatsApp/Skype/Wechat/LINE: 86 13213167925











Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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