Product Name:    4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

Synonyms:    4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide;Glyburide Related Compound A (25 mg) (5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide);4-[2-(2-Methoxy-5-chlorobenzene-1-carboxaMido)ethyl]benzenesulfonaMide;5-Chloro-N-(p-sulfaMoylphenethyl)-o-anisaMide;5-Chloro-2-Methoxy-N-(4-sulfaMoylphenethyl)benzaMide;GlibenclaMide (Glyburide) IMpurity A;Glyburide Related CoMpound A;Glyburide Related Compound A (25 mg) (4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide)

CAS:    16673-34-0

MF:    C16H17ClN2O4S

MW:    368.84

EINECS:    240-722-5

Product Categories:    Pharmaceuticals;Aromatics,Pharmaceuticals;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds;Aromatics;Intermediates & Fine Chemicals

NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising?in vivo?protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2?Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2