CAS:83-43-2
MF:C22H30O5
MW:374.47
EINECS:201-476-4
Synonyms:(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione;11,17,21-trihydroxy-6-methyl-1,4-pregnadiene-3,20-dione ;11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione;11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione;1-dehydro-6alpha-methylhydrocortisone ;20-dione,11,17,21-trihydroxy-6-methyl-,(6alpha,11beta)-pregna-4-diene-3 ;20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-4-diene-3 ;20-dione,11beta,17,21-trihydroxy-6alpha-methyl-pregna-4-diene-3

Properties

Melting point:228-237°C (dec.)
refractive index 82 ° (C=1, Dioxane)
storage temp. 0-6°C
solubility chloroform/methanol (9:1): 50 mg/mL, clear, faintly yellow
Merck 6111

Safety Information

Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-36-26
WGK Germany 2
RTECS TU4146000
F 8-10-23

Uses and Fuction

Like most adrenocortical steroids, methylprednisolon is typically used for its anti-inflammatory effects. However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methylprednisolon is prescribed is rather long, and is similar to other corticosteroids such as prednisolone. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. It is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notablysystemic lupus erythematosus. It is also used as a treatment for multiple sclerosis.

Another potential use of methylprednisolon is for vestibular neuritis.

After egg retrieval for a cycle of in vitro fertilization, methylprednisolon may be prescribed to prevent the body from rejecting the embryos being transferred, up to the time of implantation.