(20S)-Protopanaxadiol NEW
| Price | $45 | $64 | $243 |
| Package | 5mg | 10mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-01 |
Product Details
| Product Name: (20S)-Protopanaxadiol | CAS No.: 30636-90-9 |
| Purity: 98.91% | Supply Ability: 10g |
| Release date: 2024/11/01 |
Product Introduction
Bioactivity
| 名稱 | (20S)-Protopanaxadiol |
| 描述 | (20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin. |
| 細(xì)胞實(shí)驗(yàn) | Int-407 and Caco-2 cells are seeded at a concentration of 1×106 cells/mL in 24-well plates in separate experiments. Test ginsenosides (PPD, PPT, Rh2) are added to wells to the LC50 concentration determined previously from the MTT assays. The ginsenoside concentrations used for Int-407 cells are 23, 26, and 53 μg/mL, respectively, for PPD, PPT, and Rh2. In a similar experiment using Caco-2 cells, 24 μg/mL for both PPD and PPT and 55 μg/mL for Rh2 is used. Untreated cells represented the control. Cells are incubated at 37℃ in a 5% CO2 humidified incubator for 24, 48, and 72 h. Cell-free supernatant are obtained by centrifugation(400 g) for 10 min, and the lactate dehydrogenase (LDH) assay is conducted as previously reported.(Only for Reference) |
| 體外活性 | Concentrations causing growth inhibition of 50% of cells (LC50) for the compounds (20S)-Protopanaxadiol is 23 μg/ml, for Int-407 cells. The the LC50 for (20S)-Protopanaxadiol is determined to be 24 μg/ml in Caco-2 cells. In the Int-407 cell line, (20S)-Protopanaxadiol produces great percentage of sub-G1 (apoptotic) cells(The Int-407 cell line is a human embryonic nonmalignant cell line originating from fetal tissue of approximately 2 months gestation, whereas Caco-2 is a human colon adenocarcinoma cell line). This response is attributed to differences in individual ginsenoside glycosylation and, thus, the hydrophobic-hydrophilic balance [2]. Incubation with (20S)-Protopanaxadiol also significantly reduces the viability of U251-MG and U87-MG cells in a dose- and time-dependent manner. The cytotoxic effect of (20S)-Protopanaxadiol is accompanied by reduced expression of cell adhesion proteins, including N-cadherin and integrin β1, which leads to reduced phosphorylation of focal adhesion kinase. Furthermore, incubation with (20S)-Protopanaxadiol reduces the expression of cyclin D1 and subsequently induces cell-cycle arrest at the G1 phase[3]. |
| 體內(nèi)活性 | Treatment with (20S)-Protopanaxadiol and PPT prior to immobilization stress increase the time spent in open arms and open arm entries in the elevated plus-maze (EPM) test. Treatment with (20S)-Protopanaxadiol potently suppresses immobilization stress-induced serum levels of corticosterone and interleukin (IL)-6 by the enzyme-linked immunosorbent assay. (20S)-Protopanaxadiol and PPT may exhibit the anxiolytic effect via γ-aminobutyrateA (GABAA) receptor(s) and serotonergic receptor(s), respectively, and (20S)-Protopanaxadiol may have an anti-inflammatory effect that is more potent than that of PPT[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 31 mg/mL (67.3 mM) DMSO : 85 mg/mL (184.6 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| 關(guān)鍵字 | ginseng | Cluster of differentiation 243 | (20S)Protopanaxadiol | 20APPD | P-glycoprotein | Apoptosis | ABCB1 | CD243 | (20S) Protopanaxadiol | Pgp | (20S)-Protopanaxadiol | MDR1 | various tumor cells | Reactive Oxygen Species | Protopanaxadiol | Multidrug resistance protein 1 | inhibit | Inhibitor | P-gp | saponins | Akt activity |
| 相關(guān)產(chǎn)品 | Stavudine | Sodium 4-phenylbutyrate | Tributyrin |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 經(jīng)典已知活性庫(kù) | 膜蛋白靶向化合物庫(kù) | 植物來(lái)源化合物庫(kù) | 中藥抗炎分子庫(kù) | 煙草單體化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 古代經(jīng)典名方目錄分子庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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