Ambrisentan
Price | $254 |
Package | 10g/Bag |
Min. Order: | 10KG |
Supply Ability: | 10kg |
Update Time: | 2024-11-14 |
Product Details
Product Name: Ambrisentan | CAS No.: 177036-94-1 |
EC-No.: 658-059-9 | Min. Order: 10KG |
Purity: 99% | Supply Ability: 10kg |
Release date: 2024/11/14 |
CAS: 177036-94-1
MF: C22H22N2O4
MW: 378.42
EINECS: 658-059-9
Melting point >150°C (dec.)
Boiling point 551.1±60.0 °C(Predicted)
density 1.228±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
Ambrisentan is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. It is the third ET-receptor antagonist to be marketed for this indication behind bosentan and sitaxsentan. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation ofETA and ETB receptors.
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- Since: 2008-05-08
- Address: No.10,the 4th road of High-tech zone, Baoji City, Shaan’xi province, Mainland China
13892490616
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