lamotrigine
Price | $200 |
Package | 1KG |
Min. Order: | 1KG |
Supply Ability: | 5000kg/month |
Update Time: | 2021-09-07 |
Product Details
Product Name: lamotrigine | CAS No.: 84057-84-1 |
EC-No.: 281-901-8 | Min. Order: 1KG |
Purity: >99% | Supply Ability: 5000kg/month |
Release date: 2021/09/07 |
Product Info:
Lamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channelTarget: Sodium ChannelLamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate [1]. In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for each) than the release of GABA (ED50 = 11.2 mg/L), and is much less potent in inhibiting acetylcholine release (ED50 = 25.6 mg/L) when cortical slices is exposed to veratrine 75 mg/L. Basal glutamate release is unaffected [2]. Lamotrigine inhibits high-frequency sustained repetitive firing of sodium-dependent action potentials, indicating a direct effect on voltage-activated sodium channels [3]. Lamotrigine (Lamictal), a phenyltriazine derivative, is a well established anticonvulsant agent that has shown efficacy in the prevention of mood episodes in adult patients with bipolar I disorder. lamotrigine significantly delayed time to intervention for a depressive episode and showed limited efficacy in delaying time to intervention for a manic/hypomanic episode, compared with placebo. Lamotrigine is generally well tolerated.
General info CAS 84057-84-1 lamotrigine anticonvulsant drug
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- Since: 2015-10-08
- Address: Room 1103-1,Haiyue Building,YuHuaXi Road, Qiaoxi District , Shijiazhuang, Hebei province