SULFATHIAZOLE sodium NEW
Price | $10 |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 100ton |
Update Time: | 2024-10-30 |
Product Details
Product Name: SULFATHIAZOLE sodium | CAS No.: 72-14-0 |
Min. Order: 1kg | Purity: 99% |
Supply Ability: 100ton | Release date: 2024/10/30 |
Specification
Test items |
Standard |
Result |
|
Description |
White to off- White powder |
Conforms |
|
Identification |
IR |
IR spectrum of sample is the same as working standard |
Conforms |
HPLC |
HPLC RT of the sample is the same as the working standard |
Conforms |
|
Melting point |
165.0°C~169.0°C |
165.8°C~167.0°C |
|
Optical rotation |
-23°~-29° |
-27.4° |
|
Loss on drying |
NMT 1.0 % |
0.17% |
|
Residue on ignition |
NMT 0.1 % |
0.03% |
|
Heavy metals |
NMT 20ppm |
Conforms |
|
Related substances |
|||
Impurity A |
NMT 0.1 % |
Not detected |
|
Impurity B |
NMT 0.1 % |
Not detected |
|
Impurity C |
NMT 0.1 % |
0.02% |
|
Single impurity |
NMT 0.2 % |
0.17% |
|
Total impurity |
NMT 1.0 % |
0.60% |
|
Assay |
NLT 99.0% |
99.0% |
Function
Posaconazole is a broadspectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14ademethylase enzyme (IC50s range from 7-200 nM), which results in a disruption the synthesis of ergosterol, a key sterol necessary for fungal cell membrane integrity and for the function of certain membranebound proteins.Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14alpha demethylase, a cytochrome P450-dependent enzyme. Posaconazole is a sterol C14a demethylase inhibitor with an IC50 of 0.25 nM. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changesthe fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14alpha demethylase. Posaconazole is the most advanced candidate for the treatment of Chagas disease. Posaconazole has entered in a phase II clinical trial in the treatment of mycoses.
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4.transport
ems,dhl, tnt, ups ,fedex, by air, by sea
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for high value products, please select air shipping and dhl express for safe;
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2. third-party test for the products you demand.
3. test your counter-samples and produce them for you.
4. best discount for old customers.
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- Since: 2015-05-06
- Address: Yuhua West Road, Qiaoxi District, Shijiazhuang,Hebei, China
+86-15531157085
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