U0126
| Price |
| Package |
| Min. Order: | 1KG |
| Supply Ability: | 10 MT/ Month |
| Update Time: | 2024-10-22 |
Product Details
| Product Name: U0126 | CAS No.: 109511-58-2 |
| Min. Order: 1KG | Purity: 95%~99.99% |
| Supply Ability: 10 MT/ Month | Release date: 2024/10/22 |
Heidi 183
| U0126 Basic information |
| Product Name: | U0126 |
| Synonyms: | U0126;1,4-DIAMINO-2,3-DICYANO-1,4-BIS(2-AMINOPHENYLTHIO)BUTADIENE;1,4-DIAMINO-2,3-DICYANO-1,4-BIS(2-AMINOPHYNYLTIO)BUTADIENE;1,4-DIAMINO-2,3-DICYANO-1,4-BIS(O-AMINOPHENYLMERCAPTO)BUTADIENE;1,4-DIAMINO-2,3-DICYANO-1;UO 126;U0126 >99%;2,3-Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile |
| CAS: | 109511-58-2 |
| MF: | C18H16N6S2 |
| MW: | 380.49 |
| EINECS: | |
| Product Categories: | Signalling;Protein Kinase;Inhibitor |
| Mol File: | 109511-58-2.mol |
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| U0126 Chemical Properties |
| Melting point | approximate 154℃(dec.) |
| Boiling point | 565.1±50.0 °C(Predicted) |
| density | 1.44 |
| RTECS | EJ9710000 |
| storage temp. | Desiccate at +4°C |
| form | White solid |
| pka | 2.11±0.10(Predicted) |
| Water Solubility | Soluble in DMSO. Poorly soluble in ethanol and water |
| Safety Information |
| MSDS Information |
| U0126 Usage And Synthesis |
| Uses | A chemically synthesized and highly selective inhibitor of both MEK1 and MEK2 with IC50s of 70 nM and 60 nM, respectively. |
| Definition | ChEBI: A dinitrile that is succinonitrile in which the methylene hydrogens at positions 2 and 3 are substituted by (2-aminophenyl)sulfanyl]methylidene groups. A potent and selective non-competitive inhibitor of MAP kinase kinase. |
| Biological Activity | Potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC 50 values of 0.07 and 0.06 μ M respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Centrally active following systemic administration in vivo . Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™ . |
Company Profile Introduction
Technology research and transfer of pilot screening, pilot scale-up and mass production solutions , for pharmaceutical intermediates, biologicals and fine chemicals (Not including inflammable , explosive , hazardous goods ) ; Market : Nano material , metal catalyst , raw material of cosmetics , pharmaceutical intermediates , chemicals , photoelectric material , import and export of technology and goods (For projects subject to approval according to law, business activities can be carried out only after approval by relevant departments ).
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $158.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
| $0.00/1kg |
VIP3Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-09-22 | |
| $30.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
| $2500.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
| $0.00/1kg |
VIP3Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-09-22 |
China- Since: 2020-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, He
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