Ranitidine Hydrochloride
| Price | $15 |
| Package | 1Kg/Bag |
| Min. Order: | 1Kg/Bag |
| Supply Ability: | 20 Tons |
| Update Time: | 2020-11-16 |
Product Details
| Product Name: Ranitidine Hydrochloride | CAS No.: 66357-59-3 |
| EC-No.: 266-333-0 | Min. Order: 1Kg/Bag |
| Purity: 99% | Supply Ability: 20 Tons |
| Release date: 2020/11/16 |
Product Name: Ranitidine Hydrochloride
Synonyms: Rantidine hydrochloride USP24;Ranitidine hydrochloride CP2000,USP24;Rantidine HCL;Ranitidine HCL BP2000/USP25;RANITIDINE HCL USP (FORM 1);RANITIDINE HCL USP (FORM 2);RANITIDINE HYDROCHLORIDE HISTAMINE H2 RE CEPTOR;Ranitidinehydrochloride,99%
CAS: 66357-59-3
MF: C13H23ClN4O3S
MW: 350.86
EINECS: 266-333-0
Product Categories: Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;AntagonistsEPA;NeatsCell Signaling Enzymes;1694 Pharmaceuticals&Personal Care Products;Histaminergics;Neurotransmitters;Substrates;Xenobiotics and Drug Metabolism;SPECTAZOLE;API
Mol File: 66357-59-3.mol
Ranitidine Hydrochloride Structure
Ranitidine Hydrochloride Chemical Properties
Melting point 134°C (dec.)
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility H2O: 1.8 mg/mL
form solid
color tan
Water Solubility Soluble in water, 2-hydroxypropyl-beta-cyclodextrin, acetic acid, methanol, ethanol and dimethyl sulfoxide. Insoluble in chloroform.
Sensitive Hygroscopic
Merck 14,8110
CAS DataBase Reference 66357-59-3(CAS DataBase Reference)
Safety Information
Hazard Codes F,T
Risk Statements 20/21/22-39/23/24/25-23/24/25-11
Safety Statements 22-24/25-45-36/37-16-7
WGK Germany 2
RTECS KM6557000
HS Code 2932190002
MSDS Information
Provider Language
SigmaAldrich English
ALFA English
Ranitidine Hydrochloride Usage And Synthesis
Background and overview Ranitidine Hydrochloride (RHCl) is a kind of histamine H2 receptor antagonist. Since its listing in 1981, ranitidine hydrochloride has been widely used in nearly one hundred countries in the world, including China. It is clinically used for the treatment of duodenal ulcer, reflux esophagitis and Zollinger-Ellison syndrome. It is also used for the prevention of gastrointestinal bleeding caused by stress ulcer and recurrent hemorrhage of peptic ulcer. In recent decade, through the combination of ranitidine and other drugs, it has found that it has high efficiency and remarkable features in the treatment of Helicobacter pylori-positive duodenal ulcer, urticaria and post-cerebral hemorrhage stress ulcer with better efficacy than other similar drugs. Owing to its rapid effect, good potency and low price, ranitidine hydrochloride plays an important role in the anti-ulcer drug market today. Therefore, strict quality control plays important roles in guiding patients with reasonable, safe medication.
Pharmacological effects This product is a H2 receptor inhibitor, being capable of inhibiting the gastric acid secretion. After oral administration, it is absorbed through the gastrointestinal tract quickly. Synthetic route [4]
The intermediates (3) and (5) were synthesized as follows. The intermediates (3) and (5) were then reacted to produce (6) ranitidine. The (6) is subject to purification and salt formation to generate ranitidine hydrochloride, as shown:
Pharmacokinetics After oral administration, it is absorbed rapidly from the gastrointestinal tract with a bioavailability (F) of about 50% and peak plasma concentration (tmax) reaching within 1 to 2 hours. Plasma protein binding rate is 15% ± 3%; effective blood concentration is 100ng / ml, widely distributed in the body with the apparent volume of distribution (Vd) of 1.1 ~ 1.9L / Kg. It can penetrate through the blood brain barrier with the drug concentration in cerebrospinal fluid being 1/30 ~ 1 / 20 of blood concentration. 30% is subject to liver metabolism with the metabolites including N-oxide, S-oxide and demethylation metabolites. 50% of the prototype is subject to urine excretion through kidney. Half-life (t1 / 2) is 2 to 3 hours, which is similar to cimetidine. Renal failure causes corresponding increase in the half-life. The goods can be transplanted via the placenta with the milk concentration being higher than the plasma concentration of drugs.
Indications For the treatment of duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome and other high acid secretion disorders.
Adverse reactions
Common reactions are: nausea, rash, constipation, fatigue, headache, dizziness and so on.
Light adverse reactions on the renal function, gonadal function and central nervous system.
A small number of patients get mild liver damage after taking the drug with the symptoms disappearing after stopping, liver function returned to normal.
Medicine interactions
Combination with procainamide reduces the clearance rate of the later one.
Drug interactions may occur if used with other medications, consult physician or pharmacist for details.
Precautions
This product mustn’t be used continuously for more than 7 days, the symptom is not relieved, consult your physician or pharmacist.
Elderly patients or patients with liver and kidney dysfunction use with caution.
If overdose or serious adverse reactions, should seek medical treatment immediately.
Disable it for people who are allergic to this product; allergies should use with caution.
This product is not allowed for administration upon change of its traits.
Please put this product where children cannot touch.
Children must be under adult guardianship.
If you are using other drugs, please consult your physician or pharmacist before using this product.
Contraindication
Children under 8 years should be disabled.
Pregnant and lactating women should be disabled.
Elderly patients medication The elderly have reduced liver and kidney function; in order to ensure drug safety, dosage should be adjusted.
Chemical Properties Off-White Crystalline Solid
Uses A histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative.
Uses antifungal
Brand name Zantac (GlaxoSmithKline).
Contact allergens Ranitidine, an H2-receptor antagonist, can cause contact dermatitis within the pharmaceutical industry and in health care workers, or may induce systemic drug reactions in patients.
Company Profile Introduction
Longyan Tianhua Biological Technology Co., Ltd is located in Longyan city, Fujian Province, China. It is a large-scale high-tech integrated enterprise dedicated to the research, development and sales of fine chemicals, pharmaceutical raw material intermediates, food and feed additives.
The company has its own research and development base, equipped with advanced production equipment and efficient and precise testing instruments, has set up a strict and scientific quality management system, and constantly committed to technological innovation, product innovation and management innovation, so as to ensure that our products have super competitiveness in the same industry.?
Company's main: Phenformin Hydrochloride, Chlorhexidine Acetate, Indomethacin Biphenyl benzyl azole dyclonine hydrochloride clorprenaline hydrochloride griseofulvin chloramphenicol maleic acid to guangxi pp qi, fucus xanthine tert-butyl of hydroxy anisole (BHA), ammonia, benzene pteridine zonisamide moxifloxacin mother nucleus moxifloxacin side chain moxifloxacin hydrochloride clobetasol propionate tranexamic acid raw material, and so on.?
The annual sales volume of the company is around 3 million DOLLARS. Its products have been sold to more than 40 countries and regions all over the world, and have been well received. Moreover, the buyback rate of customers is very high.
Longyan Tianhua Biotechnology Co., LTD. Is looking forward to long-term cooperation with you.
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China- Since: 2019-10-11
- Address: Room 201, 11 Xinhouying Road, Xicheng Lian, Xinluo District, Longyan City, Fujian Province, China
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