β-Nicotinamide mononucleotide NEW
| Price | $30 | $46 | $71 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: β-Nicotinamide mononucleotide | CAS No.: 1094-61-7 |
| Purity: 99.66% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | β-Nicotinamide mononucleotide |
| Description | β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism. |
| In vitro | METHODS: Human corneal epithelial cells HCECs were treated with glucose (25 mM) and β-nicotinamide mononucleotide (5-1000 μM) for 48 h. Cell viability was measured by Trypan blue staining. RESULTS: The effects of different concentrations of β-nicotinamide mononucleotide on HCEC damage induced by high glucose were analyzed. 125, 250 and 500 μM β-nicotinamide mononucleotide showed significant protective effects. [1] METHODS: Late passaged MSCs LP MSCs were treated with β-nicotinamide mononucleotide (100 μM) for 24 h and mitochondrial morphology was analyzed. RESULTS: The mitochondrial staining in LP-MSCs was more diffuse and less intense, while the distribution of mitochondria became concentrated after β-nicotinamide mononucleotide treatment. β-nicotinamide mononucleotide treatment could effectively normalize the mitochondrial morphology and improve the function of mitochondria in senescent MSCs. [2] |
| In vivo | METHODS: To study the effects on aging, β-nicotinamide mononucleotide (100-300 mg/kg) was administered in drinking water to normally aging wild-type C57BL/6N mice. The administration began at 5 months of age and continued for 12 months until the mice were 17 months old. RESULTS: β-nicotinamide mononucleotide effectively attenuated age-related physiological decline in mice. β-nicotinamide mononucleotide did not have any significant toxic or deleterious effects, inhibited age-related weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and lipid levels, and improved insulin resistance. sensitivity and lipid levels, and improved eye function and other pathophysiology. [3] |
| Storage | keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : Insoluble H2O : 50 mg/mL（149.60 mM), Sonication is recommended. |
| Keywords | Alzheimer's | inhibit | obesity | Endogenous Metabolite | b-NM | Inhibitor | intermediate | diabetes | NAD | cardioprotection | b-Nicotinamide mononucleotide | cancer | βNicotinamide mononucleotide | β Nicotinamide mononucleotide | beta-Nicotinamide mononucleotide | beta-NM | β-Nicotinamide mononucleotide | disease |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Natural Product Library | Natural Product Library for HTS | Human Endogenous Metabolite Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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